d(+)-histidinol dihydrochloride
d(+)-histidinol dihydrochloride structure
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Common Name | d(+)-histidinol dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 75614-84-5 | Molecular Weight | 214.093 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C6H13Cl2N3O | Melting Point | 193-195ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
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TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.
J. Biol. Chem. 286 , 403-9, (2011) Topoisomerase II (Top2) activity involves an intermediate in which the topoisomerase is covalently bound to a DNA double-strand break via a 5'-phosphotyrosyl bond. Although these intermediates are normally transient, they can be stabilized by antitumor agents... |
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