2,2,3,3-TETRAMETHYLCYCLOPROPANECARBOXYLIC ACID
2,2,3,3-TETRAMETHYLCYCLOPROPANECARBOXYLIC ACID structure
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Common Name | 2,2,3,3-TETRAMETHYLCYCLOPROPANECARBOXYLIC ACID | ||
|---|---|---|---|---|
| CAS Number | 15641-58-4 | Molecular Weight | 142.19600 | |
| Density | 0.999 g/cm3 | Boiling Point | 204.8ºC at 760 mmHg | |
| Molecular Formula | C8H14O2 | Melting Point | 120-121 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 97.5ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue.
Epilepsy Res. 98(2-3) , 238-46, (2012) Valproic acid (VPA) is a major antiepileptic drug (AED) that is less potent than other AEDs. 2,2,3,3-Tetramethylcyclopropanecarboxylic acid (TMCA) is an inactive cyclopropyl analogue of VPA that serves as a starting material for the synthesis of CNS-active co... |
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Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid.
J. Med. Chem. 52 , 2233-42, (2009) 2,2,3,3-Tetramethylcyclopropanecarboxylic acid (TMCA, 4) is a cyclic analogue of the antiepileptic drug (AED) valproic acid (VPA) (1). alpha-F, alpha-Cl, alpha-Br, and alpha-methyl derivatives of 4 and their amides were synthesized and tested in rodent models... |
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Histone deacetylases inhibition and tumor cells cytotoxicity by CNS-active VPA constitutional isomers and derivatives.
Biochem. Pharmacol. 69(10) , 1501-8, (2005) The tumor cells toxicity of the antiepileptic drug valproic acid (VPA) has been associated with the inhibition of histone deacetylases (HDACs). We have assessed, in comparison to VPA, the HDACs inhibition and tumor cells cytotoxicities of CNS-active VPA's con... |
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Preparation of tetramethylcyclopropanecarboxylic-14C acid and insecticidal terallethrin-14C from it.
Radioisotopes 30(8) , 452-4, (1981)
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