Nafoxidine HCl
Nafoxidine HCl structure
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Common Name | Nafoxidine HCl | ||
|---|---|---|---|---|
| CAS Number | 1847-63-8 | Molecular Weight | 462.023 | |
| Density | 1.137g/cm3 | Boiling Point | 574.5ºC at 760mmHg | |
| Molecular Formula | C29H32ClNO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 176.7ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Prediction of ligand binding affinity using a multiple-conformations-multiple-protonation scheme: application to estrogen receptor α.
Chem. Pharm. Bull. 60(2) , 183-94, (2012) A fast method that can predict the binding affinities of chemicals to a target protein with a high degree of accuracy will be very useful in drug design and regulatory science. We have been developing a scoring function for affinity prediction, which can be a... |
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Tamoxifen and related compounds protect against lipid peroxidation in isolated nuclei: relevance to the potential anticarcinogenic benefits of breast cancer prevention and therapy with tamoxifen?
Free Radic. Biol. Med. 17(5) , 485-8, (1994) Tamoxifen, 4-hydroxytamoxifen, nafoxidine, 17 beta-oestradiol and ICI 164,384 were all found to protect rat liver nuclei against Fe(III)-ascorbate dependent lipid peroxidation. The order of effectiveness of these compounds was 4-hydroxytamoxifen > 17 beta-oes... |
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Multifactorial activities of nonsteroidal antiestrogens against leukemia.
Cancer Detect. Prev. 27(5) , 389-96, (2003) The antileukemic activity of nonsteroidal antiestrogens was investigated. Tamoxifen, clomiphene and nafoxidine caused a decrease in viability of the estrogen receptor-negative T-lymphoblastic leukemia cell line CCRF/CEM, nafoxidine being the most active. A co... |
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Genistein effects on growth and cell cycle of Candida albicans.
J. Biomed. Sci. 8(2) , 153-9, (2001) Microbial virulence is generally considered to be multifactorial with infection resulting from the sum of several globally regulated virulence factors. Estrogen may serve as a signal for global virulence induction in Candida albicans. Nonsteroidal estrogens a... |
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Bepridil enhances in vitro antitumor activity of antiestrogens in human brain tumor cells.
Cancer Lett. 110(1-2) , 243-8, (1996) The possible interaction between antiestrogens (tamoxifen, clomiphene and nafoxidine) and bepridil, a known Na+-Ca2+ exchange blocker, in the regulation of cell growth was investigated using U-373 MG human astrocytoma and SK-N-MC human neuroblastoma cells as ... |
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Non-steroidal antiestrogens induce apoptosis in HL60 and MOLT3 leukemic cells; involvement of reactive oxygen radicals and protein kinase C.
Anticancer Res. 19 , 2089, (1999) The antitumoral activity of non-steroidal antiestrogens on promyelocytic leukemia HL60 and T lymphoblastic MOLT3 cell lines was studied. Tamoxifen and its derivatives, clomiphene and nafoxidine, caused reduction of cell viability in a dose-dependent manner. T... |
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Evaluation of clinical and environmental anti-estrogens with human estrogen receptor expressed in Saccharomyces cerevisiae: a novel role for ABC-cassette transporters in mediating anti-estrogenic activity.
Biochem. Biophys. Res. Commun. 235 , 669, (1997) The effectiveness of anti-estrogens in treating estrogen-dependent diseases is limited by the acquired resistance of some diseases to anti-estrogens. This effect could occur by the export of anti-estrogens by cell membrane transport proteins. To study this ph... |
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Comparison of the antiproliferative properties of antiestrogenic drugs (nafoxidine and clomiphene) on glioma cells in vitro.
Am. J. Clin. Oncol. 27(4) , 384-8, (2004) The antitumoral activity of nonsteroidal antiestrogens on C6 and low passage of human glioma cells was investigated. Tamoxifen and its metabolite, 4-hydroxytamoxifen, did not influence viability of the human cells, but tamoxifen had a limited antiproliferativ... |
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Nafoxidine modulates the expression of matrix-metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in endothelial cells.
Anticancer Res. 20(1A) , 395-400, (2000) During angiogenesis, proteases and their inhibitors interact in the remodelling of the basement membrane. It has been demonstrated that nafoxidine has antiangiogenic activity in the chick egg chorioallantoic membrane assay, but the precise mechanism of action... |
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Hormonal regulation of sialic acid-binding (SAS) protein synthesis of rat uterus.
Mol. Cell Biochem. 124(2) , 115-20, (1993) Sialic acid binding proteins (SAS) of rat uteri have been found in all three stages of the estrous cycle. To study the control of synthesis of these proteins two different animal models were used I-immature female rats (25 d) where the hormones estradiol (E2)... |