8-Cyclopentyl-1,3-dimethylxanthine
8-Cyclopentyl-1,3-dimethylxanthine structure
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Common Name | 8-Cyclopentyl-1,3-dimethylxanthine | ||
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| CAS Number | 35873-49-5 | Molecular Weight | 248.28100 | |
| Density | 1.332g/cm3 | Boiling Point | 513.1ºC at 760mmHg | |
| Molecular Formula | C12H16N4O2 | Melting Point | 250-252ºC | |
| MSDS | Chinese USA | Flash Point | 264.1ºC | |
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Cold plasma treatment for the microbiological safety of cabbage, lettuce, and dried figs.
Food Microbiol. 51 , 74-80, (2015) Microwave-powered cold plasma treatment (CPT) was evaluated as a means to improve the microbiological safety of fresh vegetables and dried fruits. The CPT at 900 W, conducted for 10 min using nitrogen as a plasma-forming gas, inactivated Salmonella Typhimuriu... |
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Cerebrospinal fluid (CSF) CD8+ T-cells that express interferon-gamma contribute to HIV associated neurocognitive disorders (HAND).
PLoS ONE 10(2) , e0116526, (2015) HIV associated neurocognitive disorders (HAND) continue to affect cognition and everyday functioning despite anti-retroviral treatment (ART). Previous studies focused on mechanisms related to monocyte/macrophage mediated inflammation. However, in the ART era,... |
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Nitric Oxide Down-Regulates Topoisomerase I and Induces Camptothecin Resistance in Human Breast MCF-7 Tumor Cells.
PLoS ONE 10 , e0141897, (2015) Camptothecin (CPT), a topoisomerase I poison, is an important drug for the treatment of solid tumors in the clinic. Nitric oxide (·NO), a physiological signaling molecule, is involved in many cellular functions, including cell proliferation, survival and deat... |
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In situ DOX-calcium phosphate mineralized CPT-amphiphilic gelatin nanoparticle for intracellular controlled sequential release of multiple drugs.
Acta Biomater. 15 , 191-9, (2015) A co-delivery strategy has been developed to achieve the synergistic effect of a hydrophobic drug (camptothecin, CPT) and a hydrophilic drug (doxorubicin, DOX) by utilizing the unique structure of amphiphilic gelatin/camptothecin @calcium phosphate-doxorubici... |
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Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.
J. Cell Biol. 208(5) , 563-79, (2015) Replication fork reversal protects forks from breakage after poisoning of Topoisomerase 1. We here investigated fork progression and chromosomal breakage in human cells in response to a panel of sublethal genotoxic treatments, using other topoisomerase poison... |
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Galectin-1 exerts inhibitory effects during DENV-1 infection.
PLoS ONE 9(11) , e112474, (2014) Dengue virus (DENV) is an enveloped RNA virus that is mosquito-transmitted and can infect a variety of immune and non-immune cells. Response to infection ranges from asymptomatic disease to a severe disorder known as dengue hemorrhagic fever. Despite efforts ... |
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Localized adenosine signaling provides fine-tuned negative feedback over a wide dynamic range of neocortical network activities.
J. Neurophysiol. 113(3) , 871-82, (2015) Although the patterns of activity produced by neocortical networks are now better understood, how these states are activated, sustained, and terminated still remains unclear. Negative feedback by the endogenous neuromodulator adenosine may potentially play an... |
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Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis.
Breast Cancer Res. 16(6) , 3413, (2015) Transducer of Cdc42-dependent actin assembly-1 (Toca-1) recruits actin regulatory proteins to invadopodia, and promotes breast tumor metastasis. Since metastatic breast tumors frequently harbor mutations in the tumor suppressor p53, we tested whether p53 regu... |
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Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.
Cell Cycle 14 , 1842-58, (2015) Polyploid decidual cells are specifically differentiated cells during mouse uterine decidualization. However, little is known about the regulatory mechanism and physiological significance of polyploidization in pregnancy. Here we report a novel role of E2F8 i... |
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EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.
Nucleic Acids Res. 43 , 7371-87, (2015) The maintenance of genome stability is critical for the suppression of diverse human pathologies that include developmental disorders, premature aging, infertility and predisposition to cancer. The DNA damage response (DDR) orchestrates the appropriate cellul... |