L-768242
L-768242 structure
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Common Name | L-768242 | ||
|---|---|---|---|---|
| CAS Number | 180002-83-9 | Molecular Weight | 447.35 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H24Cl2N2O3 | Melting Point | 47-49°C(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells.
Cell Death Dis. 4 , e664, (2013) The anti-tumoral effects of cannabinoids have been described in different tumor systems, including pancreatic adenocarcinoma, but their mechanism of action remains unclear. We used cannabinoids specific for the CB1 (ACPA) and CB2 (GW) receptors and metabolomi... |
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Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism.
Cell Death Dis. 2 , e152, (2011) Gemcitabine (GEM, 2',2'-difluorodeoxycytidine) is currently used in advanced pancreatic adenocarcinoma, with a response rate of < 20%. The purpose of our work was to improve GEM activity by addition of cannabinoids. Here, we show that GEM induces both cannabi... |
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