Geneticin
Geneticin structure
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Common Name | Geneticin | ||
|---|---|---|---|---|
| CAS Number | 108321-42-2 | Molecular Weight | 692.709 | |
| Density | N/A | Boiling Point | 1012.1ºC at 760mmHg | |
| Molecular Formula | C20H44N4O18S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 565.9ºC | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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Soluble endoglin antagonizes Met signaling in spindle carcinoma cells.
Carcinogenesis 36(2) , 212-22, (2015) Increased levels of soluble endoglin (Sol-Eng) correlate with poor outcome in human cancer. We have previously shown that shedding of membrane endoglin, and concomitant release of Sol-Eng is a late event in chemical mouse skin carcinogenesis associated with t... |
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Novel siRNA delivery system using a ternary polymer complex with strong silencing effect and no cytotoxicity.
Biol. Pharm. Bull. 37(8) , 1274-81, (2014) We developed a novel small interfering RNA (siRNA) delivery system using a ternary complex with polyethyleneimine (PEI) and γ-polyglutamic acid (γ-PGA), which showed silencing effect and no cytotoxicity. The binary complexes of siRNA with PEI were approximate... |
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Human olfactory bulb neural stem cells mitigate movement disorders in a rat model of Parkinson's disease.
J. Cell Physiol. 230(7) , 1614-29, (2015) Parkinson's disease (PD) is a neurological disorder characterized by the loss of midbrain dopaminergic (DA) neurons. Neural stem cells (NSCs) are multipotent stem cells that are capable of differentiating into different neuronal and glial elements. The produc... |
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Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine.
PLoS ONE 10 , e0128653, (2015) Mexiletine and lidocaine are widely used class IB anti-arrhythmic drugs that are considered to act by blocking voltage-gated open sodium currents for treatment of ventricular arrhythmias and relief of pain. To gain mechanistic insights into action of anti-arr... |
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Oxidative Stress Increases Surface Toll-Like Receptor 4 Expression in Murine Macrophages Via Ceramide Generation.
Shock 44 , 157-65, (2015) Multiorgan failure is a major cause of late mortality following trauma. Oxidative stress generated during shock/resuscitation contributes to tissue injury by priming the immune system for an exaggerated response to subsequent inflammatory stimuli, such as lip... |
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Generation and characterisation of a canine EGFP-HMGA2 prostate cancer in vitro model.
PLoS ONE 9(6) , e98788, (2014) The architectural transcription factor HMGA2 is abundantly expressed during embryonic development. In several malignant neoplasias including prostate cancer, high re-expression of HMGA2 is correlated with malignancy and poor prognosis. The let-7 miRNA family ... |
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TXNDC17 promotes paclitaxel resistance via inducing autophagy in ovarian cancer.
Autophagy 11(2) , 225-38, (2015) Paclitaxel is recommended as a first-line chemotherapeutic agent against ovarian cancer, but drug resistance becomes a major limitation of its success clinically. The key molecule or mechanism associated with paclitaxel resistance in ovarian cancer still rema... |
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Identities of P2 and P3 Residues of H-2Kb-Bound Peptides Determine Mouse Ly49C Recognition.
PLoS ONE 10 , e0131308, (2015) Ly49 receptors can be peptide selective in their recognition of MHC-I-peptide complexes, affording them a level of discrimination beyond detecting the presence or absence of specific MHC-I allele products. Despite this ability, little is understood regarding ... |
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JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2/STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma.
Neuro. Oncol. 16(9) , 1229-43, (2014) As a commonly mutated form of the epidermal growth factor receptor, EGFRvIII strongly promotes glioblastoma (GBM) tumor invasion and progression, but the mechanisms underlying this promotion are not fully understood.Through gene manipulation, we established E... |
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Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.
Exp. Cell Res. 331(2) , 369-76, (2015) Nodal modulator 1 (NOMO1), a highly conserved transmembrane protein, has been identified as a part of a protein complex that participates in the Nodal signaling pathway, a critical determinant of heart and visceral organ formation. We previously found that th... |