Carbenicillin disodium
Carbenicillin disodium structure
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Common Name | Carbenicillin disodium | ||
|---|---|---|---|---|
| CAS Number | 4800-94-6 | Molecular Weight | 422.363 | |
| Density | N/A | Boiling Point | 737.8ºC at 760 mmHg | |
| Molecular Formula | C17H16N2Na2O6S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 400ºC | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis.
PLoS ONE 9(4) , e93953, (2014) Trisubstituted benzimidazoles have demonstrated potency against Gram-positive and Gram-negative bacterial pathogens. Previously, a library of novel trisubstituted benzimidazoles was constructed for high throughput screening, and compounds were identified that... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.
J. Biol. Chem. 282 , 23841-53, (2007) Organic anion transporters (OATs, SLC22) interact with a remarkably diverse array of endogenous and exogenous organic anions. However, little is known about the structural features that determine their substrate selectivity. We examined the substrate binding ... |
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Spray-Dried Multiscale Nano-biocomposites Containing Living Cells.
ACS Nano 9 , 6961-77, (2015) Three-dimensional encapsulation of cells within nanostructured silica gels or matrices enables applications as diverse as biosensors, microbial fuel cells, artificial organs, and vaccines; it also allows the study of individual cell behaviors. Recent progress... |
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Carbon-14 radiolabeling and in vivo biodistribution of a potential anti-TB compound.
J. Labelled Comp. Radiopharm. 58(2) , 23-9, (2015) A potential anti-TB compound bearing a nitroimidazole moiety from iThemba Pharmaceuticals TB chemical library exhibits promising in vitro activity in the microplate almar blue assay (MABA) with a minimum inhibitory concentration (MIC) value of 3 µg/mL. It is ... |
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Inhaled antibiotics for pulmonary exacerbations in cystic fibrosis.
Cochrane Database Syst. Rev. 12 , CD008319, (2012) Cystic fibrosis is a genetic disorder in which abnormal mucus in the lungs is associated with susceptibility to persistent infection. Pulmonary exacerbations are when symptoms of infection become more severe. Antibiotics are an essential part of treatment for... |
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Alternative sigma factors in the free state are equilibrium mixtures of open and compact conformations.
Biochemistry 49 , 9809-9819, (2010) Conformational switching upon core RNA polymerase binding is an integral part of functioning of bacterial sigma factors. Here, we have studied dynamical features of two alternative sigma factors. A study of fluorescence resonance energy transfer and hydrodyna... |
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Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni.
Antimicrob. Agents Chemother. 53 , 3357-64, (2009) Fifty-two percent of 1,288 poultry isolates of campylobacters were ampicillin resistant, and resistance was more common among Campylobacter coli isolates (67.4%) than among Campylobacter jejuni isolates (47.5%). Production of beta-lactamase was typically asso... |
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Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms.
J. Mol. Biol. 405(1) , 173-84, (2011) We report the first crystal structures of a penicillin-binding protein (PBP), PBP3, from Pseudomonas aeruginosa in native form and covalently linked to two important β-lactam antibiotics, carbenicillin and ceftazidime. Overall, the structures of apo and acyl ... |
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Efficient embryogenic suspension culturing and rapid transformation of a range of elite genotypes of sweet potato (Ipomoea batatas [L.] Lam.).
Plant Sci. 181(6) , 701-11, (2011) Efficient Agrobacterium tumefaciens-mediated transformation was developed using embryogenic suspension cell cultures of elite sweet potato (Ipomoea batatas [L.] Lam.) cultivars, including Ayamurasaki, Sushu2, Sushu9, Sushu11, Wanshu1, Xushu18 and Xushu22. Emb... |