Chloropyramine hydrochloride
Chloropyramine hydrochloride structure
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Common Name | Chloropyramine hydrochloride | ||
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| CAS Number | 6170-42-9 | Molecular Weight | 326.26400 | |
| Density | N/A | Boiling Point | 413.5ºC at 760 mmHg | |
| Molecular Formula | C16H21Cl2N3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 203.9ºC | |
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A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cells.
Cell Cycle 13(16) , 2542-53, (2014) Melanoma has the highest mortality rate of all skin cancers and a major cause of treatment failure is drug resistance. Tumors heterogeneity requires novel therapeutic strategies and new drugs targeting multiple pathways. One of the new approaches is targeting... |
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Inhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma.
Mol. Carcinog. 54(1) , 9-23, (2015) Neuroblastoma is the most common extracranial solid tumor of childhood and is responsible for over 15% of pediatric cancer deaths. Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that is important in many facets of tumor development and progressi... |
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[Discriminant function analysis in the assessment of laboratory test data in the correction of traditional therapy for mild icteric form of viral hepatitis B in children with food allergy].
Klin. Lab. Diagn. (6) , 17-22, (2010) The purpose of this investigation was to define the efficiency of inclusion of antihistamines (suprastin or tavegil), enzyme drugs (pancreatin or mesim forte) and their combinations into therapy for a mild icteric form of acute viral hepatitis B (VHB) in chil... |
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Effects of chloropyramine, dimethindene and diphenhydramine on transepithelial ion transport: studies in bovine tracheal epithelium and frog skin.
J. Physiol. (Paris) 81(3) , 185-90, (1986) The effects on transepithelial ion transports of chloropyramine, dimetindene and diphenhydramine, which are three antagonists of H1-receptors of histamine, were examined in bovine tracheal epithelium and in frog skin. The short-circuit current I0 across bovin... |
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[Interaction of pipolfen and suprastin with human serum albumin depending on the pH of the medium and its calcium ion content].
Farmakol. Toksikol. 46(6) , 59-63, (1983) Experiments made with the use of equilibrium dialysis and differential spectrophotometry have shown that pipolfen and difenhydramine interact actively with human serum albumin at pH 6.8-7.4. Calcium ions have been demonstrated to activate the interaction of p... |
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[Toxico-allergic form of erythema multiforme exudativum caused by suprastin].
Vestn. Dermatol. Venerol. (9) , 50-1, (1986)
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Effect of substance P administration on vascular permeability in the rat oral mucosa and sublingual gland.
J. Periodont. Res. 30(3) , 181-5, (1995) Neuropeptides, including substance P (SP) may play a role in neurogenic inflammation. Although SP-immunoreactive (SP-IR) axons are known to be present within the oral mucosa (OM) and salivary glands, the functional significance of SP in oral mucosa and sublin... |
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[Functional and morphological status of the gastric mucosa mast cells on the administration of dimedrol and suprastin].
Farmakol. Toksikol. 46(1) , 34-7, (1983) Histochemical and morphometric analysis of mast cells of the gastric and duodenal mucosa of rats given dyphenhydramine and suprastin for a long period of time (up to 45 days) revealed an increase in their functional activity that manifested in the enhancement... |
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[Characteristics of dimedrol, pipolfen and suprastin absorption from the small intestine of rats in systemic anaphylactic shock].
Farmakol. Toksikol. 51(2) , 85-8, (1988) It was shown by the in situ method that absorption of dimedrol, pipolphen and suprastine from the small intestine of the rats immunized parenterally with ovalbumin against the background of intravenous administration of the resolving dose of ovalbumin signifi... |
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[Dependence of the absorption through the human oral mucosa of antihistaminic (H1) preparations on their physicochemical properties].
Farmakol. Toksikol. 51(1) , 75-9, (1988) Antihistaminic (H1) drugs pipolphen, suprastin and dimedrol are characterized according to absorption through human oral mucosa and distribution between phosphate buffer solution and organic solvents at various medium pH values. Their constants of ionization ... |