Atovaquone
Atovaquone structure
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Common Name | Atovaquone | ||
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| CAS Number | 95233-18-4 | Molecular Weight | 366.837 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 542.2±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H19ClO3 | Melting Point | 216-2190C | |
| MSDS | Chinese USA | Flash Point | 281.7±30.1 °C | |
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CYP2C19*17 increases clopidogrel-mediated platelet inhibition but does not alter the pharmacokinetics of the active metabolite of clopidogrel.
Clin. Exp. Pharmacol. Physiol. 41(11) , 870-8, (2014) The aim of the present study was to determine the impact of CYP2C19*17 on the pharmacokinetics and pharmacodynamics of the active metabolite of clopidogrel and the pharmacokinetics of proguanil. Thus, we conducted an open-label two-phase cross-over study in 3... |
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A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.
Sci. Transl. Med. 7 , 290ra89, (2015) Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved drugs for emerging infections remains a critical ... |
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Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity.
Malaria Journal 13 , 359, (2014) Therapeutic blood plasma concentrations of anti-malarial drugs are essential for successful treatment. Pharmacokinetics of pharmaceutical compounds are dependent of adsorption, distribution, metabolism, and excretion. ATP binding cassette (ABC) transport prot... |
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Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery.
Sci. Rep. 5 , 15930, (2015) The spread of Plasmodium falciparum multidrug resistance highlights the urgency to discover new targets and chemical scaffolds. Unfortunately, lack of experimentally validated functional information about most P. falciparum genes remains a strategic hurdle. C... |
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Effects of slow-release urea and rumen-protected methionine and histidine on performance of dairy cows.
J. Dairy Sci. 98(5) , 3292-308, (2015) This experiment was conducted with the objective to investigate the effects of slow-release urea and rumen-protected (RP) Met and His supplementation of a metabolizable protein (MP)-deficient diet (according to NRC, 2001) on lactation performance of dairy cow... |
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Artemether-lumefantrine compared to atovaquone-proguanil as a treatment for uncomplicated Plasmodium falciparum malaria in travelers.
Am. J. Trop. Med. Hyg. 92(1) , 13-7, (2015) Atovaquone-proguanil (AP) and artemether-lumefantrine (AL) are both treatments for uncomplicated Plasmodium falciparum malaria, but comparative clinical trials are lacking. We performed a retrospective analysis, comparing treatment failure and fever clearance... |
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Bridging strategies for drug combinations in pediatric indications.
Clin. Pharmacol. Ther. 91 , 726-33, (2012) Concurrent prescription of different drugs is common and is often necessary in many pediatric indications. A randomized concentration-controlled trial (RCCT) is proposed for pediatric studies in which drug combinations are used. The aim of our investigation w... |
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Efficacy and safety of atovaquone–proguanil in treating imported malaria in Japan: The second report from the research group
Parasitol. Int. 61(3) , 466-9, (2012) Malaria remains an important health risk among travelers to tropical/subtropical regions. However, in Japan, only 2 antimalarials are licensed for clinical use — oral quinine and mefloquine. The Research Group on Chemotherapy of Tropical Diseases introduced a... |
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Lead clinical and preclinical antimalarial drugs can significantly reduce sporozoite transmission to vertebrate populations.
Antimicrob. Agents Chemother. 59(1) , 490-7, (2014) To achieve malarial elimination, we must employ interventions that reduce the exposure of human populations to infectious mosquitoes. To this end, numerous antimalarial drugs are under assessment in a variety of transmission-blocking assays which fail to meas... |
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Effect of dietary protein level and rumen-protected amino acid supplementation on amino acid utilization for milk protein in lactating dairy cows.
J. Dairy Sci. 98(3) , 1885-902, (2015) This study investigated the effect of metabolizable protein (MP) supply and rumen-protected (RP) Lys and Met supplementation on productivity, nutrient digestibility, urinary N losses, apparent total-tract digestibility of dietary AA, and the efficiency of AA ... |