Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Atovaquone
Price: ￥306.0/10mg ￥1016.0/50mg ￥606.0/25mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Atovaquone (Atavaquone)
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Atovaquone
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Atovaquone
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

95233-18-4

95233-18-4 structure

Name: Atovaquone
Chemical Name: atovaquone
CAS Number: 95233-18-4
Molecular Formula: C₂₂H₁₉ClO₃
Molecular Weight: 366.837
Catalog: API Synthetic anti-infective drugs Antiviral drugs
Create Date: 2018-05-07 08:00:00
Modify Date: 2024-01-02 17:57:31
Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.Target: AntiparasiticAtovaquone (atavaquone) is a chemical compound that belongs to the class of naphthalenes. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity [1]. Atovaquone is an anti-protozoal mitochondrial electron transport inhibitor; Antimalarial; Antipneumocystic, and has also been used to treat toxoplasmosis. It acts by inhibiting the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket [2]. Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis [3].

Name	atovaquone
Synonyms	2-Propanol,1-[2-(4-methyl-1,3-dioxolan-2-yl)ethoxy] 2-[trans-4-(4'-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone 1,2-Naphthalenedione, 3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxy- MFCD00889188 3-(4-(4-chlorophenyl)cyclohexyl)-4-hydroxy-naphthalene-1,2-dione trans-2-[2-(2-hydroxypropoxy)-ethyl]-4-methyl-1,3-dioxolane Atovaquone trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone 3-[4-(4-Chlorophenyl)cyclohexyl]-4-hydroxy-1,2-naphthalenedione 2-(trans-4-(4-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthalenedione (trans-2-hydroxy-3-(4-(4-chlorophenyl)cyclohexyl)-1,4-naphthoquinone)

Description	Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.Target: AntiparasiticAtovaquone (atavaquone) is a chemical compound that belongs to the class of naphthalenes. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity [1]. Atovaquone is an anti-protozoal mitochondrial electron transport inhibitor; Antimalarial; Antipneumocystic, and has also been used to treat toxoplasmosis. It acts by inhibiting the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket [2]. Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis [3].
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
References	[1]. Looareesuwan, S., et al., Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand. Am J Trop Med Hyg, 1996. 54(1): p. 62-6. [2]. Kessl, J.J., et al., Molecular basis for atovaquone binding to the cytochrome bc1 complex. J Biol Chem, 2003. 278(33): p. 31312-8. [3]. Baggish, A.L. and D.R. Hill, Antiparasitic agent atovaquone. Antimicrobial agents and chemotherapy, 2002. 46(5): p. 1163-1173.

Density	1.4±0.1 g/cm3
Boiling Point	542.2±50.0 °C at 760 mmHg
Melting Point	216-2190C
Molecular Formula	C₂₂H₁₉ClO₃
Molecular Weight	366.837
Flash Point	281.7±30.1 °C
Exact Mass	366.102264
PSA	54.37000
LogP	5.86
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.653
Storage condition	-20°C Freezer

Hazard Statements	H413
Hazard Codes	N
Risk Phrases	50/53
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	QJ5616500
HS Code	2942000000

137732-39-9

~85%

95233-18-4

Literature: WO2010/1378 A1, ; Page/Page column 11 ;

94015-53-9

~78%

95233-18-4

Literature: US2010/137644 A1, ; Page/Page column 3-4 ;

129719-64-8

~93%

95233-18-4

Literature: Tetrahedron Letters, , vol. 39, # 42 p. 7629 - 7632

94015-53-9

137732-39-9

95233-18-4

Literature: WO2012/153162 A1, ; Page/Page column 33 ;

1010-60-2

95233-18-4

Literature: Tetrahedron Letters, , vol. 39, # 42 p. 7629 - 7632

1409957-21-6

~74%

95233-18-4

Literature: WO2013/14486 A1, ; Page/Page column 27; 28 ;

95233-37-7

95233-18-4

Literature: Tetrahedron Letters, , vol. 39, # 42 p. 7629 - 7632

Precursor 5
1409957-21-6 94015-53-9 129719-64-8 1010-60-2
95233-37-7
DownStream 0

HS Code	2914700090
Summary	HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

95233-18-4	2070015-14-2
1329792-63-3	137732-39-9
1217612-80-0	6632-81-1
92458-44-1	1163294-17-4