Pizotifen
Pizotifen structure
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Common Name | Pizotifen | ||
|---|---|---|---|---|
| CAS Number | 15574-96-6 | Molecular Weight | 295.442 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 436.7±45.0 °C at 760 mmHg | |
| Molecular Formula | C19H21NS | Melting Point | 140-142°C | |
| MSDS | Chinese USA | Flash Point | 217.9±28.7 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Method development for impurity profiling in SFC: The selection of a dissimilar set of stationary phases.
J. Pharm. Biomed. Anal. 111 , 333-43, (2015) Supercritical fluid chromatography (SFC) is drawing considerable interest as separation technique in the pharmaceutical industry. The technique is already well established in chiral separations both analytically and on a preparative scale. The use of SFC as a... |
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Efficacy of amitriptyline, pizotifen and propranolol in the prevention of migraine.
Mymensingh Med. J. 22(1) , 93-100, (2013) This intervention study conducted in the Neurology outpatient Department of Mymensingh Medical College Hospital (MMCH) from January 2006 to December 2007 to compare efficacy of amitriptyline, pizotifen and propranolol in the prophylaxis of migraine. Ninety ca... |
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Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat.
Eur. J. Pharmacol. 535(1-3) , 234-42, (2006) This study set out to analyse the potential ability of some 5-hydroxytryptamine (5-HT) receptor ligands widely used in cardiovascular experimental models to interact with vascular alpha1-adrenoceptors in the pithed rat. These ligands included: methiothepin, m... |
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Agomelatine(S 20098) antagonizes the penile erections induced by the stimulation of 5-HT2C receptors in Wistar rats.
Psychopharmacology 170(1) , 17-22, (2003) Agomelatine, an antidepressant with melatonin agonist and 5-HT(2C) antagonist properties, as well as two of its main metabolites, S 21517 (N-[2-(7-hydroxy-1-naphtyl)ethyl]acetamide) and S21540 (N-[2-(3-hydroxy-7-methoxynaphtalen-1-yl)ethyl]acetamide), have be... |
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Serotonin2C receptor blockade and thermoregulation during exercise in the heat.
Med. Sci Sports Exerc. 37(3) , 389-94, (2005) The effect of serotonin (5-HT)2C receptor blockade on the thermal response and exercise performance during exercise in a warm environment was examined.Seven endurance-trained, but not heat-acclimatized, individuals (six males and one female) performed two 40-... |
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Do pizotifen or propranolol reduce the frequency of migraine headache?
Arch. Dis. Child. 89(7) , 684-5, (2004)
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Weight gain with pizotifen therapy.
Arch. Dis. Child. 93(7) , 590-3, (2008) To describe the characteristics of weight gain occurring in children treated for migranous conditions with pizotifenRetrospective case note reviewWest Suffolk Hospital between 1999 and 2003 PATIENTS: 405 clinic attendances of 121 children receiving pizotifen ... |
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Pizotyline effectively attenuates the stimulus effects of N-methyl-3,4-methylenedioxyamphetamine (MDMA).
Pharmacol. Biochem. Behav. 82(2) , 404-10, (2005) MDMA (N-methyl-3,4-methylenedioxyamphetamine) produces a discriminative stimulus (DS) effect in animals, but attempts to completely block this action with selective neurotransmitter antagonists have not been very successful. Biochemically, MDMA can increase s... |
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Solubility of solid dispersions of pizotifen malate and povidone.
Drug Dev. Ind. Pharm. 27(6) , 517-22, (2001) We analyzed the physicochemical characteristics of solid dispersions of pizotifen malate and povidone (Kollidon 12) at different proportions; we used X-ray diffraction, infrared spectrometry and differential scanning calorimetry (DSC) and tested the solubilit... |
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P3MC: a double blind parallel group randomised placebo controlled trial of Propranolol and Pizotifen in preventing migraine in children.
Trials 11 , 71, (2010) A recent Cochrane Review demonstrated the remarkable lack of reliable clinical trials of migraine treatments for children, especially for the two most prescribed preventative treatments in the UK, Propranolol and Pizotifen.Migraine trials in both children and... |