S-15176 difumarate salt
S-15176 difumarate salt structure
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Common Name | S-15176 difumarate salt | ||
|---|---|---|---|---|
| CAS Number | 148913-55-7 | Molecular Weight | 776.93300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C39H56N2O12S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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S-15176 inhibits mitochondrial permeability transition via a mechanism independent of its antioxidant properties.
Eur. J. Pharmacol. 468 , 93-101, (2003) Mitochondrial Ca(2+) accumulation can induce a sudden increase in the permeability of the inner membrane. This phenomenon is due to the generation of a large nonselective ion channel, termed the permeability transition pore (PTP), which contributes to cellula... |
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Inhibition of mitochondrial carnitine palmitoyltransferase-1 by a trimetazidine derivative, S-15176.
Pharmaceut. Res. 44 , 99-104, (2001) The purpose of this study was to investigate the possible effect of the trimetazidine derivative S-15176 on carnitine palmitoyltransferase1 (CPT-1) activity in rat heart and liver mitochondria. S-15176 was compared with the other antianginal agents amiodarone... |
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S-15176 reduces the hepatic injury in rats subjected to experimental ischemia and reperfusion.
Eur. J. Pharmacol. 406 , 281-292, (2000) The protective effect of N-[(3, 5-di-tertiobutyl-4-hydroxy-1-thiophenyl)]-3-propyl-N'-(2,3, 4-trimethoxybenzyl)piperazine (S-15176) on liver injury induced by warm ischemia-reperfusion was investigated using a rat model. Animals were subjected to 2 h of ische... |
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The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure.
Herz. 27 , 621-636, (2002) Partial fatty acid oxidation inhibitors have raised great interest since they are expected to counteract a dysregulated gene expression of hypertrophied cardiocytes. Some of these compounds have been developed for treating non-insulin-dependent diabetes melli... |
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S-15176 and its methylated derivative suppress the CsA-insensitive mitochondrial permeability transition and subsequent cytochrome c release induced by silver ion, and show weak protonophoric activity.
Mol. Cell Biochem. 358(1-2) , 45-51, (2011) A recent report has described that S-15176 (N-[(3,5-di-tert-butyl-4-hydroxy-1-thiophenyl)]-3-propyl-N'-(2,3,4-trimethoxybenzyl) piperazine), an anti-ischemic agent, inhibits the mitochondrial permeability transition (PT) induced by not only Ca(2+) and inorgan... |