Okadaic acid
Okadaic acid structure
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Common Name | Okadaic acid | ||
|---|---|---|---|---|
| CAS Number | 78111-17-8 | Molecular Weight | 805.003 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 921.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C44H68O13 | Melting Point | 164-166ºC | |
| MSDS | Chinese USA | Flash Point | 269.4±27.8 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Uptake of neutrophil-derived Ym1 protein distinguishes wound macrophages in the absence of interleukin-4 signaling in murine wound healing.
Am. J. Pathol. 184(12) , 3249-61, (2014) The determination of regenerative wound-healing macrophages as alternatively activated macrophages is currently questioned by the absence of IL-4 in wound tissue. Yet, murine wound tissue expressed high levels of Ym1 (chitinase 3-like 3), an established marke... |
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Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores.
J. Cell Biol. 208(2) , 181-96, (2015) During mitosis, the spindle checkpoint senses kinetochores not properly attached to spindle microtubules and prevents precocious sister-chromatid separation and aneuploidy. The constitutive centromere-associated network (CCAN) at inner kinetochores anchors th... |
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Direct cellular delivery of human proteasomes to delay tau aggregation.
Nat. Commun. 5 , 5633, (2014) The 26S proteasome is the primary machinery that degrades ubiquitin (Ub)-conjugated proteins, including many proteotoxic proteins implicated in neurodegeneraton. It has been suggested that the elevation of proteasomal activity is tolerable to cells and may be... |
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Ram seminal plasma proteins contribute to sperm capacitation and modulate sperm-zona pellucida interaction.
Theriogenology 83(4) , 670-8, (2015) Incubation of ram spermatozoa in capacitating conditions with cAMP-elevating agents promotes a progressive time-dependent increase in the capacitated sperm subpopulation. In this study, the fertilizing capacity of ram spermatozoa (ability to bind to the zona ... |
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Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.
Proc. Natl. Acad. Sci. U. S. A. 112 , 6712-7, (2015) Dynamic changes in synaptic strength are thought to be critical for higher brain function such as learning and memory. Alterations in synaptic strength can result from modulation of AMPA receptor (AMPAR) function and trafficking to synaptic sites. The phospho... |
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Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts.
Biochem. Pharmacol. 95 , 311-23, (2015) Different lines of evidence indicate that the lysophosphatidic acid (LPA) receptor LPA1 is involved in neurogenesis, synaptic plasticity and anxiety-related behavior, but little is known on whether this receptor can be targeted by neuropsychopharmacological a... |
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ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation.
Autophagy 11 , 1308-25, (2015) Recent studies have shown that the phosphorylation and dephosphorylation of ULK1 and ATG13 are related to autophagy activity. Although ATG16L1 is absolutely required for autophagy induction by affecting the formation of autophagosomes, the post-translational ... |
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T cells and lung injury. Impact of rapamycin.
Am. J. Respir. Cell. Mol. Biol. 51(2) , 294-9, (2014) Acute lung injury (ALI) is characterized by pulmonary inflammation and edema. Innate immune cells (e.g., neutrophils and macrophages) are major contributors to inflammation in ALI. Less is known regarding the role of T cells. We examined the effects of rapamy... |
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KIF4A and PP2A-B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle.
J. Cell Biol. 207(6) , 683-93, (2014) The mitotic kinase Aurora B is concentrated at the anaphase central spindle by the kinesin MKlp2 during mitotic exit and cytokinesis. This pool of Aurora B phosphorylates substrates including the kinesin KIF4A to regulate central spindle length. In this paper... |
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Phosphoproteomic Analysis of Aurora Kinase Inhibition in Monopolar Cytokinesis.
J. Proteome Res. 14 , 4087-98, (2015) Cytokinesis is the last step of the cell cycle that requires coordinated activities of the microtubule cytoskeleton, actin cytoskeleton, and membrane compartments. Aurora B kinase is one of the master regulatory kinases that orchestrate multiple events during... |