Ganglioside GT1b Mixture (bovine) (ammonium salt)
Ganglioside GT1b Mixture (bovine) (ammonium salt) structure
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Common Name | Ganglioside GT1b Mixture (bovine) (ammonium salt) | ||
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| CAS Number | 59247-13-1 | Molecular Weight | 2180.424 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C95H174N8O47 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity.
Biochemistry 52(22) , 3930-8, (2013) Botulinum neurotoxins (BoNTs) block neurotransmitter release by proteolyzing SNARE proteins in peripheral nerve terminals. Entry into neurons occurs subsequent to interaction with gangliosides and a synaptic vesicle protein. Isoforms I and II of synaptotagmin... |
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Distribution of mono-, di- and trisialo gangliosides in the brain of Actinopterygian fishes
Biochim. Biophys. Acta 1820(9) , 1437-43, (2012) Background Mono-, di- and trisialo gangliosides are major glycosphingolipids in the brain of higher vertebrates involved in lipid raft assembly. In contrast, the fish brain is abundant in polisialo-gangliosides, whose function is implicated in the modulation ... |
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Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex.
Proc. Natl. Acad. Sci. U. S. A. 85 , 7351-7355, (1988) Using a sensitive histofluorescence staining method that allows for a quantitation of neuronal death, we compared the protective effects of gangliosides (a group of naturally occurring glycosphingolipids), phencyclidine (PCP), and MK-801 (dibenzocycloheptenei... |
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GM1 / GD1b / GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line.
Cancer Sci. 101(9) , 2039-47, (2010) Gangliosides are expressed in neuroectoderm-derived tumors, and seemed to play roles in the regulation of cancer properties. To examine the behavior and roles of individual gangliosides, GM1/GD1b/GA1 synthase cDNA was introduced into the melanoma cell line SK... |
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Botulinum neurotoxins B and E translocate at different rates and exhibit divergent responses to GT1b and low pH.
Biochemistry 51(28) , 5655-62, (2012) Botulinum neurotoxins (BoNTs, serotypes A-G) are the most deadly substances known. Here, we investigated how BoNT/E, a serotype that causes human botulism, translocates into the cytosol of neurons. Analogous to BoNT/B, BoNT/E required binding of the corecepto... |
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Conformational analysis of GT1B ganglioside and its interaction with botulinum neurotoxin type B: a study by molecular modeling and molecular dynamics.
J. Biomol. Struct. Dyn. 30(3) , 255-68, (2012) The conformational property of oligosaccharide GT1B in aqueous environment was studied by molecular dynamics (MD) simulation using all-atom model. Based on the trajectory analysis, three prominent conformational models were proposed for GT1B. Direct and water... |
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Enhancing the protective immune response against botulism.
Infect. Immun. 81(7) , 2638-44, (2013) The need for a vaccine against botulism has increased since the discontinuation of the pentavalent (ABCDE) botulinum toxoid vaccine by the Centers for Disease Control and Prevention. The botulinum toxins (BoNTs) are the primary virulence factors and vaccine c... |
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Altered ganglioside expression modulates the pathogenic mechanism of thyroid-associated ophthalmopathy by increase in hyaluronic acid.
Invest. Ophthalmol. Vis. Sci. 52(1) , 264-73, (2011) The aim of this study was to determine the role of gangliosides in pathogenic mechanisms of thyroid-associated ophthalmopathy (TAO).The gangliosides profile and mRNA level of sialyltransferases of the orbital tissues from TAO patients (n = 5) and non-TAO subj... |
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Mammalian sialyltransferase ST3Gal-II: its exchange sialylation catalytic properties allow labeling of sialyl residues in mucin-type sialylated glycoproteins and specific gangliosides.
Biochemistry 50(44) , 9475-87, (2011) While glycosyltransferases are known to display unidirectional enzymatic activity, recent studies suggest that some can also catalyze readily reversible reactions. Recently, we found that mammalian sialyltransferase ST3Gal-II can catalyze the formation of CMP... |
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Model for studying Clostridium botulinum neurotoxin using differentiated motor neuron-like NG108-15 cells.
Biochem. Biophys. Res. Commun. 427(2) , 426-30, (2012) Cancerous cell lines have traditionally shown low sensitivity to laboratory or pharmaceutical preparations of botulinum neurotoxin. The work presented here demonstrates that the mouse neuroblastoma/rat glioma hybrid cell line NG108-15 is capable of more sensi... |