Cordycepin
Cordycepin structure
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Common Name | Cordycepin | ||
|---|---|---|---|---|
| CAS Number | 73-03-0 | Molecular Weight | 251.242 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 627.2±65.0 °C at 760 mmHg | |
| Molecular Formula | C10H13N5O3 | Melting Point | 225-229ºC | |
| MSDS | Chinese USA | Flash Point | 333.1±34.3 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Involvement of autophagy in cordycepin-induced apoptosis in human prostate carcinoma LNCaP cells.
Environ. Toxicol. Pharmacol. 38(1) , 239-50, (2014) Cordycepin, an active ingredient of the insect fungus Cordyceps spp., shows strong antioxidant and anticancer activities. Several molecular mechanisms have been attributed to its inhibitory effects on a wide range of tumor cells; however, the mechanism causin... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Anti-HCV activity of the Chinese medicinal fungusCordyceps militaris
Biochem. Biophys. Res. Commun. 447(2) , 341-5, (2014) • Cordyceps militaris (CM) had a moderate anti-HCV activity for RNA replication. • Cordycepin is a responsible compound for the anti-HCV activity of CM. • CM would be a useful anti-HCV agent in combination with IFN-α and/or RBV. |
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Apoptotic effect of cordycepin combined with cisplatin and/or paclitaxel on MA-10 mouse Leydig tumor cells.
Onco. Targets Ther. 8 , 2345-60, (2015) Chemotherapy is not limited to a single treatment, and the evidence demonstrates that different drug combinations can have positive results in patients. In this study, we sought to determine whether cordycepin combined with cisplatin and/or paclitaxel would h... |
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Dereplication of known nucleobase and nucleoside compounds in natural product extracts by capillary electrophoresis-high resolution mass spectrometry.
Molecules 20 , 5423-37, (2015) Nucleobase and nucleoside compounds exist widely in various organisms. An often occurring problem in the discovery of new bioactive compounds from natural products is reisolation of known nucleobase and nucleoside compounds. To resolve this problem, a capilla... |
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Zinc triggers a complex transcriptional and post-transcriptional regulation of the metal homeostasis gene FRD3 in Arabidopsis relatives.
J. Exp. Bot. 66 , 3865-78, (2015) In Arabidopsis thaliana, FRD3 (FERRIC CHELATE REDUCTASE DEFECTIVE 3) plays a central role in metal homeostasis. FRD3 is among a set of metal homeostasis genes that are constitutively highly expressed in roots and shoots of Arabidopsis halleri, a zinc hyperacc... |
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Translational control of Arabidopsis meristem stability and organogenesis by the eukaryotic translation factor eIF3h.
PLoS ONE 9(4) , e95396, (2014) Essentially all aboveground plant tissues develop from the stem cells in the primary shoot apical meristem. Proliferation of the stem cell population in the Arabidopsis shoot apical meristem is tightly controlled by a feedback loop formed primarily by the hom... |
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Geminivirus Activates ASYMMETRIC LEAVES 2 to Accelerate Cytoplasmic DCP2-Mediated mRNA Turnover and Weakens RNA Silencing in Arabidopsis.
PLoS Pathog. 11 , e1005196, (2015) Aberrant viral RNAs produced in infected plant cells serve as templates for the synthesis of dsRNAs. The derived virus-related small interfering RNAs (siRNA) mediate cleavage of viral RNAs by post-transcriptional gene silencing (PTGS), thus blocking virus mul... |
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Characterization of DNA substrate specificities of apurinic/apyrimidinic endonucleases from Mycobacterium tuberculosis.
DNA Repair (Amst.) 33 , 1-16, (2015) Apurinic/apyrimidinic (AP) endonucleases are key enzymes involved in the repair of abasic sites and DNA strand breaks. Pathogenic bacteria Mycobacterium tuberculosis contains two AP endonucleases: MtbXthA and MtbNfo members of the exonuclease III and endonucl... |
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Preparation, spectroscopy and molecular modelling studies of the inclusion complex of cordycepin with cyclodextrins.
Carbohydr. Res. 406 , 55-64, (2015) The inclusion complexes of cordycepin with cyclodextrins (CDs) were prepared, the resultant complexes were characterised by UV-vis, FTIR, DSC, SEM, XRD, ESI-MS and proton nuclear magnetic resonance spectroscopy ((1)H NMR). The stoichiometry was established us... |