Nigericin sodium salt
Nigericin sodium salt structure
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Common Name | Nigericin sodium salt | ||
|---|---|---|---|---|
| CAS Number | 28643-80-3 | Molecular Weight | 746.943 | |
| Density | 1.19g/cm3 | Boiling Point | 779.9ºC at 760mmHg | |
| Molecular Formula | C40H67NaO11 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 226.9ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns.
Cell Death Dis. 5 , e1494, (2014) Apoptosis, which is anti-inflammatory, and necrosis, which is pro-inflammatory, represent the extremes of the cell death spectrum. Cell death is complex and both apoptosis and necrosis can be observed in the same cells or tissues. Here, we introduce a novel c... |
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In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383.
Pharm. Res. 32 , 3937-51, (2015) To assess accumulation and lysosomal sequestration of 9 drugs used in respiratory indications (plus imipramine as positive control) in the alveolar macrophage (AM) cell line NR8383.For all drugs, uptake at 5 μM was investigated at 37 and 4°C to delineate acti... |
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Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling.
J. Biol. Chem. 290 , 20167-84, (2015) We recently described the induction of noncanonical IL-1β processing via caspase-8 recruited to ripoptosome signaling platforms in myeloid leukocytes. Here, we demonstrate that activated NLRP3·ASC inflammasomes recruit caspase-8 to drive IL-1β processing in m... |
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The marine toxin palytoxin induces necrotic death in HaCaT cells through a rapid mitochondrial damage.
Toxicol. Lett. 229(3) , 440-50, (2014) Palytoxin (PLTX) is one of the most toxic algal biotoxin known so far. It transforms the Na(+)/K(+)-ATPase into a cationic channel inducing a massive intracellular Na(+) influx. However, from a mechanistic point of view, the features and the intracellular pat... |
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Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome.
Nat. Commun. 6 , 6115, (2015) Excessive activation of the NLRP3 inflammasome results in damaging inflammation, yet the regulators of this process remain poorly defined. Herein, we show that the orphan nuclear receptor small heterodimer partner (SHP) is a negative regulator of NLRP3 inflam... |
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Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain.
Pain 156(3) , 451-9, (2015) Inflammatory hyperalgesia is a complex process that depends on the sensitization of primary nociceptive neurons triggered by proinflammatory mediators, such as interleukin 1β (IL-1β). Recently, the peripheral activation of caspase-1 (previously known as IL-1β... |
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Changes in the activity of defense mechanisms against induced acidosis during meiotic maturation in mouse oocytes.
Theriogenology 75 , 1057-66, (2011) Previous work has indicated that although activity of the HCO₃⁻/Cl⁻exchanger (AE), which regulates intracellular alkalosis, is high in the germinal vesicle (GV) stage, the oocyte is inhibited as it progresses through meiotic maturation. In this study, we aime... |
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An improved flow cytometry assay to monitor phagosome acidification.
J. Immunol. Methods 412 , 1-13, (2014) Phago-lysosome formation is important for cell-autonomous immunity to intracellular pathogens, antigen presentation and metabolism. A hallmark feature of phago-lysosomal compartments is that they undergo progressive luminal acidification controlled by the act... |
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Up-regulation of avian uncoupling protein in cold-acclimated and hyperthyroid ducklings prevents reactive oxygen species production by skeletal muscle mitochondria.
BMC Physiol. 10 , 5, (2010) Although identified in several bird species, the biological role of the avian homolog of mammalian uncoupling proteins (avUCP) remains extensively debated. In the present study, the functional properties of isolated mitochondria were examined in physiological... |
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Aberrant expression of interleukin-1β and inflammasome activation in human malignant gliomas.
PLoS ONE 9(7) , e103432, (2014) Glioblastoma is the most frequent and malignant form of primary brain tumor with grave prognosis. Mounting evidence supports that chronic inflammation (such as chronic overactivation of IL-1 system) is a crucial event in carcinogenesis and tumor progression. ... |