Milnacipran hydrochloride
Milnacipran hydrochloride structure
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Common Name | Milnacipran hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 101152-94-7 | Molecular Weight | 282.809 | |
| Density | N/A | Boiling Point | 393ºC at 760 mmHg | |
| Molecular Formula | C15H23ClN2O | Melting Point | 179-181ºC | |
| MSDS | Chinese USA | Flash Point | 48.2 °F | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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The influence of caffeine on the activity of moclobemide, venlafaxine, bupropion and milnacipran in the forced swim test in mice.
Life Sci. 136 , 13-8, (2015) Worrying data indicate that excessive caffeine intake applies to patients suffering from mental disorders, including depression. It is thus possible to demonstrate the usefulness of caffeine and its derivatives in the treatment of depression. The main goal of... |
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Milnacipran inhibits oxaliplatin-induced mechanical allodynia through spinal action in mice.
Biol. Pharm. Bull. 38(1) , 151-4, (2015) We investigated whether milnacipran, a serotonin-noradrenaline reuptake inhibitor, would have therapeutic effect on oxaliplatin-induced mechanical allodynia in mice. A single intraperitoneal injection of oxaliplatin (3 mg/kg) induced mechanical allodynia, whi... |
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Prolonged administration of antidepressant drugs leads to increased binding of [(3)H]MPEP to mGlu5 receptors.
Neuropharmacology 84 , 46-51, (2014) Metabotropic glutamate 5 (mGlu5) receptors are functionally connected with NMDA receptors. The antidepressant activity of the NMDA receptor antagonist ketamine in both preclinical and clinical studies, along with the antidepressant-like activities of negative... |
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Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (Z) hydrochloride, a potential fourth generation antidepressant drug.
Neuropharmacology 24 , 1211-1219, (1985) The present study of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane(Z) hydrochloride, was undertaken to determine its biochemical profile. The properties of midalcipran, in inhibiting the uptake of monoamines were tested and... |
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Dual serotonin and noradrenaline uptake inhibitor class of antidepressants potential for greater efficacy or just hype?
Fortschr. Arzneimittelforsch. 58 , 169-222, (2002) Preclinical and clinical studies support the rationale that development of single molecules, which would promote serotonergic and noradrenergic neurotransmission by inhibiting simultaneously the uptake of both monoamines, would potentially result in improved ... |
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Pharmacological effects of milnacipran, a new antidepressant, given repeatedly on the alpha1-adrenergic and serotonergic 5-HT2A systems.
J. Neural Transm. Gen. Sect. 107 , 1345-1359, (2000) Milanacipran (MIL) is a representative of a new class of antidepressants (SNRIs) which inhibit selectively the reuptake of serotonin and noradrenaline but, in contrast to tricyclics, show no affinity for neurotransmitter receptors. The present study was aimed... |