3,3'-Diindolylmethane
3,3'-Diindolylmethane structure
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Common Name | 3,3'-Diindolylmethane | ||
|---|---|---|---|---|
| CAS Number | 1968-05-4 | Molecular Weight | 246.307 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 504.8±30.0 °C at 760 mmHg | |
| Molecular Formula | C17H14N2 | Melting Point | 167 °C | |
| MSDS | USA | Flash Point | 232.5±15.8 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Actinobacillus pleuropneumoniae induces SJPL cell cycle arrest in G2/M-phase and inhibits porcine reproductive and respiratory syndrome virus replication.
Virol. J. 12 , 188, (2015) Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens in the swine industry and causes important economic losses. No effective antiviral drugs against it are commercially available. We recently reported that the cu... |
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The extended version of restriction analysis approach for the examination of the ability of low-molecular-weight compounds to modify DNA in a cell-free system.
Food Chem. Toxicol. 75 , 118-27, (2015) One of the primary requirements in toxicology is the assessment of ability of chemicals to induce DNA covalent modification. There are several well-established methods used for this purpose such as (32)P-Postlabeling or HPLC-MS. However, all of these approach... |
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The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers.
PLoS ONE 9(12) , e115663, (2014) Cytoplasmic constitutive active/androstane receptor (CAR) retention protein (CCRP and also known as DNAJC7) is a co-chaperone previously characterized to retain nuclear receptor CAR in the cytoplasm of HepG2 cells. Here we have produced CCRP knockout (KO) mic... |
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Effect of propylene glycol on adipose tissue mobilization in postpartum over-conditioned Holstein cows.
J. Dairy Sci. 98 , 8581-96, (2015) Our objective was to investigate the quantitative and qualitative effects of propylene glycol (PG) allocation on postpartum adipose tissue mobilization in over-conditioned Holstein cows. Nine ruminally cannulated and arterially catheterized cows were, at part... |
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SOXE transcription factors form selective dimers on non-compact DNA motifs through multifaceted interactions between dimerization and high-mobility group domains.
Sci. Rep. 5 , 10398, (2015) The SOXE transcription factors SOX8, SOX9 and SOX10 are master regulators of mammalian development directing sex determination, gliogenesis, pancreas specification and neural crest development. We identified a set of palindromic SOX binding sites specifically... |
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Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR.
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Prevention of biofilm formation by methacrylate-based copolymer films loaded with rifampin, clarithromycin, doxycycline alone or in combination.
Pharm. Res. 32(1) , 61-73, (2015) This study reports the incorporation of the antibiotics rifampin, doxycycline and clarithromycin in poly(styrene-co-methyl methacrylate films and their effect on biofilm prevention.Invasive procedures in patients such as surgical device, or intravenous or uri... |
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The One Year Fate of Iron Oxide Coated Gold Nanoparticles in Mice.
ACS Nano 9 , 7925-39, (2015) Safe implementation of nanotechnology and nanomedicine requires an in-depth understanding of the life cycle of nanoparticles in the body. Here, we investigate the long-term fate of gold/iron oxide heterostructures after intravenous injection in mice. We show ... |
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Mesenchymal stromal cells reset the scatter factor system and cytokine network in experimental kidney transplantation.
BMC Immunol. 15 , 44, (2014) In former studies we showed in a rat model of renal transplantation that Mesenchymal Stromal Cells (MSC) prevent acute rejection in an independent way of their endowing in the graft. In this study we investigated whether MSC operate by resetting cytokine netw... |
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Intranasal delivery of liposomal indole-3-carbinol improves its pulmonary bioavailability.
Int. J. Pharm. 477(1-2) , 96-101, (2014) Indole-3-carbinol (I3C), a constituent of commonly consumed Brassica vegetables, has been shown to have anticancer effects in a variety of preclinical models of lung cancer. However, it has shown only limited efficacy in clinical trials, likely due to its poo... |