Indole-3-carbinol
Indole-3-carbinol structure
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Common Name | Indole-3-carbinol | ||
|---|---|---|---|---|
| CAS Number | 700-06-1 | Molecular Weight | 147.174 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 360.6±17.0 °C at 760 mmHg | |
| Molecular Formula | C9H9NO | Melting Point | 96-99 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 171.9±20.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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The extended version of restriction analysis approach for the examination of the ability of low-molecular-weight compounds to modify DNA in a cell-free system.
Food Chem. Toxicol. 75 , 118-27, (2015) One of the primary requirements in toxicology is the assessment of ability of chemicals to induce DNA covalent modification. There are several well-established methods used for this purpose such as (32)P-Postlabeling or HPLC-MS. However, all of these approach... |
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Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog.
Biochim. Biophys. Acta 1853(1) , 244-53, (2015) A major obstacle to successful treatment of hepatocellular carcinoma (HCC) is its high resistance to cytotoxic chemotherapy due to overexpression of multidrug resistance genes. Activation of the AKT pathway is known to be involved in chemoresistance in HCC; h... |
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In vitro activity of glucosinolates and their degradation products against brassica-pathogenic bacteria and fungi.
Appl. Environ. Microbiol. 81(1) , 432-40, (2014) Glucosinolates (GSLs) are secondary metabolites found in Brassica vegetables that confer on them resistance against pests and diseases. Both GSLs and glucosinolate hydrolysis products (GHPs) have shown positive effects in reducing soil pathogens. Information ... |
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[Results of open multicenter study of the safety of doxazosin in combination with indigal in men with stages I-II prostatic adenoma].
Urologiia. (2) , 42-4, 46, (2013) The article presents a method of conservative treatment of men with I-II stage prostatic adenoma using a combination of doxazosin and indigal, which has antioxidant, antiproliferative and anti-inflammatory properties, that allowed improving urodynamic paramet... |
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Effects of indole-3-carbinol and phenethyl isothiocyanate on bile and pancreatic juice excretion in rats.
J. Med. Invest. 59(3-4) , 246-52, (2012) Bile and pancreatic juice contain a number of parameters for cancer chemoprevention. Indole-3-carbinol (I3C) and phenethyl isothiocyanate (PEITC), which are hydrolytic products of brassica plants, have been established to be anti-cancer agents. Here, we devel... |
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Involvement of PTEN/Akt signaling and oxidative stress on indole-3-carbinol (I3C)-induced hepatocarcinogenesis in rats.
Exp. Toxicol. Pathol. 65(6) , 845-52, (2013) We previously reported that indole-3-carbinol (I3C) had hepatocellular tumor-promoting activity in a short-term (8 weeks) two-stage liver carcinogenesis model in rats. It was suggested that this effect was related to the production of reactive oxygen species ... |
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Protective Effects of Indole-3-Carbinol-Loaded Poly(lactic-co-glycolic acid) Nanoparticles Against Glutamate-Induced Neurotoxicity.
J. Nanosci. Nanotechnol. 15 , 7922-8, (2016) Indole-3-carbinol (I3C) has anti-oxidant and anti-inflammatory properties. Nonetheless, the potential of I3C to treat neurodegenerative diseases remains unclear because of its poor ability to penetrate the blood-brain barrier (BBB). Because polymer-based drug... |
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Induction of endoplasmic reticulum stress response by the indole-3-carbinol cyclic tetrameric derivative CTet in human breast cancer cell lines.
PLoS ONE 7(8) , e43249, (2012) Indole-3-carbinol and its metabolic products are considered promising chemopreventive and anticancer agents. Previously we have shown that the indole-3-carbinol cyclic tetrameric derivative CTet induces autophagy and inhibits cell proliferation via inhibition... |
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Sensitization of TRAIL-induced apoptosis in human hepatocellular carcinoma HepG2 cells by phytochemicals.
Life Sci. 92(10) , 555-61, (2013) The present study investigated and compared the potential chemosensitizing effect of indole-3-carbinol (I3C) and epigallocatechin-3-gallate (EGCG) on TRAIL-induced apoptosis in human hepatocellular carcinoma (HCC) HepG2 cells as well as the possible mechanism... |
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Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: Maternal diets rich in indole-3-carbinol versus sulforaphane
Toxicol. Appl. Pharmacol. 270(1) , 60-9, (2013) Cruciferous vegetable components have been documented to exhibit anticancer properties. Targets of action span multiple mechanisms deregulated during cancer progression, ranging from altered carcinogen metabolism to the restoration of epigenetic machinery. Fu... |