Naphth(1,8-cd)-1,2-oxathiole, 2,2-dioxide
Naphth(1,8-cd)-1,2-oxathiole, 2,2-dioxide structure
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Common Name | Naphth(1,8-cd)-1,2-oxathiole, 2,2-dioxide | ||
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| CAS Number | 83-31-8 | Molecular Weight | 206.218 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 419.5±18.0 °C at 760 mmHg | |
| Molecular Formula | C10H6O3S | Melting Point | 154-157 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 207.5±21.2 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Studies of the chemical selectivity of hapten, reactivity, and skin sensitization potency. 1. Synthesis and studies on the reactivity toward model nucleophiles of the (13)C-labeled skin sensitizers hex-1-ene- and hexane-1,3-sultones.
Chem. Res. Toxicol. 14(1) , 110-7, (2001) The potent skin sensitizers hex-1-ene- and hexane-1,3-sultone have been synthesized isotopically labeled with (13)C at reactive sites. The reactivity of 2-[(13)C]- and 3-[(13)C]hex-1-ene-1,3-sultones and of 3-[(13)C]hexane-1,3-sultone toward a series of model... |
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Studies of the chemical selectivity of hapten, reactivity, and skin sensitization potency. 2. nmr studies of the covalent binding of the (13)c-labeled skin sensitizers 2-[13C]- and 3-[13C]hex-1-ene- and 3-[13C]hexane-1,3-sultones to human serum albumin.
Chem. Res. Toxicol. 14(1) , 118-26, (2001) 3-[(13)C]- and 2-[(13)C]hex-1-ene-1,3-sultones (1a and 1b, respectively) and 3-[(13)C]hex-1-ene-1,3-sultone 2a were incubated with human serum albumin in phosphate buffer at pH 8.1. In both cases, the main reaction was a hydrolysis via an S(N) reaction at pos... |
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4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus.
J. Med. Chem. 52(6) , 1582-91, (2009) We report the synthesis and antiviral activity of a new family of non-nucleoside antivirals, derived from the 4-keto-1,2-oxathiole-2,2-dioxide (beta-keto-gamma-sultone) heterocyclic system. Several 4- and 5-substituted-5H-1,2-oxathiole-2,2-dioxide derivatives... |
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DNA adducts of lactones, sultones, acylating agents and acrylic compounds.
IARC Sci. Publ. (125) , 179-98, (1994)
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Single injection adjuvant test.
Curr. Probl. Dermatol. 14 , 201-7, (1985)
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A rationale for the selection of occlusion to induce and elicit delayed contact hypersensitivity in the guinea pig. A prospective test.
Curr. Probl. Dermatol. 14 , 39-58, (1985)
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Delta-sultone formation through Rh-catalyzed C-H insertion.
Org. Lett. 9(21) , 4363-6, (2007) Rhodium-catalyzed reactions of sulfonate ester derivatives are biased strongly toward 1,6-insertion and thus offer a general method for assembling delta-sultones. Two protocols for staging this cyclization reaction are described, which capitalize on the uniqu... |
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The derivation of quantitative correlations between skin sensitisation and physio-chemical parameters for alkylating agents, and their application to experimental data for sultones.
J. Theor. Biol. 99(4) , 807-25, (1982)
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Chloroalkylsulfonate ionic liquids by ring opening of sultones with organic chloride salts.
Chem. Commun. (Camb.) (33) , 3867-9, (2008) An efficient route to prepare ionic liquids with chloroalkylsulfonate anions is presented; the synthesis proceeds in a one-step ring-opening reaction of sultones with an organic chloride salt and provides a very attractive access to new anion functionalised i... |
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Synthesis and reactivity of a bis-sultone cross-linker for peptide conjugation and [18F]-radiolabelling via unusual "double click" approach.
Org. Biomol. Chem. 10(5) , 1068-78, (2012) A novel homobifunctional cross-linker based on a bis-sultone benzenic scaffold was synthesised. The potential utility of this bioconjugation reagent was demonstrated through the preparation of an original prosthetic group suitable for the [(18)F]-labelling of... |