p-Tolyl Isocyanate
p-Tolyl Isocyanate structure
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Common Name | p-Tolyl Isocyanate | ||
|---|---|---|---|---|
| CAS Number | 622-58-2 | Molecular Weight | 133.147 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 190.6±19.0 °C at 760 mmHg | |
| Molecular Formula | C8H7NO | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 63.9±24.1 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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p-Tolyl isocyanate derivatization for analysis of CWC-related polar degradation products by mass spectrometry.
Anal. Bioanal. Chem 406(21) , 5093-102, (2014) Most of the precursors and/or degradation products related to the Chemical Weapons Convention (CWC) are polar. Identification of these molecules in environmental samples provides clues regarding the alleged usage and/or synthesis of the parent toxic chemicals... |
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Antigens which detect IgE antibodies in workers sensitive to toluene diisocyanate.
Clin. Allergy 10(1) , 101-9, (1980) Two antigens, both containing tolyl groups, were compared for ability to detect IgE antibodies in workers hypersensitive to toluene diisocyanate. One antigen, formed by reaction of p-tolyl isocyanate with human serum albumin, detected antibodies in each of te... |
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A study of serum antibody activity in workers with occupational exposure to diphenylmethane diisocyanate.
Allergy 40(5) , 314-20, (1985) The prevalence of sensitization was studied in a group of 76 foundry workers with occupational exposure to diphenylmethane diisocyanate (MDI). Ten workers had clinical evidence of asthma, 40 had non-asthmatic respiratory symptoms, and 26 were asymptomatic. Sp... |
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[Technology of producing p-toluene isocyanate (C6H4CH3NCO) and a human albumin complex for clinical purposes].
Acta Pol. Pharm. 44(2) , 237-41, (1987)
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Development and loss of toluene diisocyanate reactivity: immunologic, pharmacologic, and provocative challenge studies.
J. Allergy Clin. Immunol. 70(4) , 231-5, (1982) Toluene diisocyanate (TDI) sensitivity accompanied by nonspecific bronchial hyperresponsiveness occurs in approximately 5% of occupationally exposed workers. We report the case of a 32-yr-old worker followed longitudinally after removal from isocyanate exposu... |
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Toluene-diisocyanate induced asthma: evaluation of antibodies in the serum of affected workers against a tolyl mono-isocyanate protein conjugate.
Clin. Allergy 11(2) , 161-8, (1981) Radioallergosorbent testing was used to look for the presence of specific IgE antibody against a para-tolyl-mono-isocyanate human serum albumin conjugate in sera from five groups of subjects. The first three groups consisted of individuals exposed to toluene ... |
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Immunologic sensitization and pulmonary hypersensitivity by repeated inhalation of aromatic isocyanates.
Toxicol. Appl. Pharmacol. 53(2) , 260-70, (1980)
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Radioallergosorbent testing with p-tolyl monoisocyanate in toluene diisocyanate workers.
Clin. Allergy 13(1) , 31-4, (1983) Sera from 149 occupationally exposed toluene diisocyanate (TDI) workers were tested by RAST with p-tolyl monoisocyanate human serum albumin (TMI-HSA). Of the seven positives, one had a history suggestive of TDI asthma and one had a rash which may have been TD... |
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Diphenylmethane diisocyanate (MDI)-induced asthma: evaluation of the immunologic responses and application of an animal model of isocyanate sensitivity.
Clin. Allergy 14(4) , 329-39, (1984) A worker developed two episodes of severe asthma 90 min after cutting a polyurethane plate made of diphenylmethane diisocyanate (MDI) using a rapidly turning carbide blade. Intradermal skin testing with MDI-human serum albumin (MDI-HSA) and p-tolyl isocyanate... |
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Australian TDI workers' sera assayed for IgE against a p-tolyl-isocyanate-human serum albumin conjugate.
Am. Ind. Hyg. Assoc. J. 43(10) , 759-63, (1982) Sera of 91 people were assayed for IgE which bound to a p-tolyl-isocyanate-human serum albumin conjugate. The sera came from 20 blood donors, 70 factory workers, and 1 casualty patient. Three factory workers had abnormally high assay values in association wit... |