H-Glu(OMe)-OMe.HCl
H-Glu(OMe)-OMe.HCl structure
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Common Name | H-Glu(OMe)-OMe.HCl | ||
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| CAS Number | 23150-65-4 | Molecular Weight | 211.643 | |
| Density | 1.129g/cm3 | Boiling Point | 224.3ºC at 760 mmHg | |
| Molecular Formula | C7H14ClNO4 | Melting Point | 89-90°C | |
| MSDS | USA | Flash Point | 76.7ºC | |
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Effects of the methyl esters of pyruvate, succinate and glutamate on the secretory response to meglitinide analogues in rat pancreatic islets.
Pharmacol. Res. 33(3) , 191-4, (1996) The insulinotropic action of the meglitinide analogues KAD-1229, A-4166 and repaglinide was examined in rat pancreatic islets deprived of exogenous nutrient or incubated in the presence of nutrient secretagogues such as D-glucose and the methyl esters of pyru... |
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Potentiation and prolongation of the insulinotropic action of glucagon-like peptide 1 by methyl pyruvate or dimethyl ester of L-glutamic acid in a type 2 diabetes animal model.
Endocrine 16(2) , 113-6, (2001) Methyl pyruvate and the dimethyl ester of L-glutamic acid were administered intravenously, as a primed constant infusion (1.0-2.0 micromol followed by 0.5-1.0 micromol/min, both expressed per gram of body wt), in adult rats that had been injected with strepto... |
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Spectrum of toxicities of amino acid methyl esters for myeloid cells is determined by distinct metabolic pathways.
Blood 79(4) , 964-71, (1992) L-leucine methyl ester (Leu-OMe), Leu-Leu-OMe, Phe-OMe, and Glu-(OMe)2 are toxic to mononuclear phagocytes (M phi) and neutrophils. In the present studies, the mechanism of this toxicity was examined. A concentration of NH4Cl known to neutralize lysosomal pH ... |
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Implication of glutamate in the kinetics of insulin secretion in rat and mouse perfused pancreas.
Diabetes 51 Suppl 1 , S99-102, (2002) It is intriguing that the kinetics of glucose-stimulated insulin secretion from the in situ perfused pancreas differ between the rat and the mouse. Here we confirm that insulin release in the rat is clearly biphasic, whereas in the mouse glucose essentially e... |
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Preparation of membrane vesicles from kidney cortex lysosomes using amino acid methyl ester.
Biochem. Mol. Biol. Int. 30(6) , 1005-11, (1993) A procedure for the preparation of intact membrane vesicles from kidney cortex lysosomes is reported. Highly purified preparations of lysosomes were isolated from rat and buffalo kidney cortex by Percoll density gradient centrifugation. The lysosomal membrane... |
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Glutamatergic and serotonergic mechanisms in the dorsal facial area for common carotid artery blood flow control in the cat.
Auton. Neurosci. 101(1-2) , 85-90, (2002) This study explored which subtyes of glutamate receptors in the dorsal facial area are involved in the interaction between glutamatergic and serotonergic actions in controlling common carotid arterial blood flow. Microinjection of glutamate (25-100 nmol), N-m... |
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Glucose metabolism and glutamate analog acutely alkalinize pH of insulin secretory vesicles of pancreatic beta-cells.
Am. J. Physiol. Endocrinol. Metab. 285(2) , E262-71, (2003) We studied acute changes of secretory vesicle pH in pancreatic beta-cells with a fluorescent pH indicator, lysosensor green DND-189. Fluorescence was decreased by 0.66 +/- 0.10% at 149 +/- 16 s with 22.2 mM glucose stimulation, indicating that vesicular pH wa... |
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Insulinotropic action of glutamic acid dimethyl ester.
Am. J. Physiol. 267(4 Pt 1) , E573-84, (1994) Glutamic acid dimethyl ester (GME; 3.0-10.0 mM) enhanced insulin release evoked by 6.0-8.3 mM D-glucose, 1.0-10.0 mM L-leucine, or 5.0-10.0 mM 2-amino-bicyclo(2,2,1)heptane-2-carboxylic acid, causing a shift to the left of the sigmoidal relationship between i... |
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[Effect of antagonists of excitatory amino acids on synaptic transmission in the electroreceptors (Lorenzini's ampullae) in skates].
Neirofiziologiia 20(4) , 457-63, (1988) Ampullae of Lorenzini isolated from the skate (Raja clavata) have been investigated in vitro electrophysiologically to determine the nature of the transmitter at the synapse between the electroreceptor cells and afferent fibres. Glutamic acid diethyl ester (G... |
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Heterogeneous secretion of individual B cells in response to D-glucose and to nonglucidic nutrient secretagogues.
Am. J. Physiol. 268(3 Pt 1) , C611-8, (1995) We used a hemolytic plaque assay for insulin to determine whether the same pancreatic B cells respond to D-glucose, 2-amino-bicyclo[2,2,1]heptane-2-carboxylic acid (BCH) and the association of this nonmetabolized analogue of L-leucine with either the monometh... |