Niclosamide
Niclosamide structure
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Common Name | Niclosamide | ||
|---|---|---|---|---|
| CAS Number | 50-65-7 | Molecular Weight | 327.120 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 424.5±45.0 °C at 760 mmHg | |
| Molecular Formula | C13H8Cl2N2O4 | Melting Point | 225-230ºC | |
| MSDS | Chinese USA | Flash Point | 210.5±28.7 °C | |
| Symbol |
GHS09 |
Signal Word | Warning | |
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The salicylanilide derivatives inhibit signal transducer and activator of transcription 3 pathways in A549 lung cancer cells.
Anticancer Drugs 27 , 41-7, (2015) The signal transducer and activator of transcription 3 (STAT3) is constitutively activated in certain cancer cells. Therefore, blocking the aberrant activity of STAT3 in tumor cells is a validated therapeutic strategy. To discover novel inhibitors of STAT3 ac... |
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Taenia solium: Development of an Experimental Model of Porcine Neurocysticercosis.
PLoS Negl. Trop. Dis. 9 , e0003980, (2015) Human neurocysticercosis (NC) is caused by the establishment of Taenia solium larvae in the central nervous system. NC is a severe disease still affecting the population in developing countries of Latin America, Asia, and Africa. While great improvements have... |
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Phase I and phase II reductive metabolism simulation of nitro aromatic xenobiotics with electrochemistry coupled with high resolution mass spectrometry.
Anal. Bioanal. Chem 406(28) , 7253-60, (2014) Electrochemistry combined with (liquid chromatography) high resolution mass spectrometry was used to simulate the general reductive metabolism of three biologically important nitro aromatic molecules: 3-trifluoromethyl-4-nitrophenol (TFM), niclosamide, and ni... |
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LGR5 is associated with tumor aggressiveness in papillary thyroid cancer.
Oncotarget 6 , 34549-60, (2015) Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a cancer stem cell marker and a down-stream target in Wnt/β-catenin signaling. In human papillary thyroid cancer (PTC), over activation of Wnt/β-catenin has been associated with tumor aggre... |
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Validation of a streamlined multiclass, multiresidue method for determination of veterinary drug residues in bovine muscle by liquid chromatography-tandem mass spectrometry.
Anal. Bioanal. Chem 407 , 4423-35, (2015) Multiclass, multiresidue methods are becoming increasingly popular in regulatory monitoring programs due to their increased analytical scope and laboratory efficiency. In this work, we report the development and validation of a new high-throughput analytical ... |
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Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells.
Cell. Signal. 25(4) , 961-9, (2013) Previous studies have demonstrated that a small subset of cancer cells is capable of tumor initiation. The existence of tumor initiating cancer stem cells (CSCs) has several implications in terms of future cancer treatment and therapies. However, recently, se... |
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Taenia saginata a rare cause of acute cholangitis: a case report.
Acta Clin. Belg. 67(6) , 436-7, (2012) Parasitic infestations of the galdbladder and biliary tract are quite rare. Taenia saginata is an intestinal helmint and patients harbouring adult T.saginata tapeworms are mostly asymptomatic and discharge only fecal proglottids. In some cases there might be ... |
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Optimizing molluscicide treatment strategies in different control stages of schistosomiasis in the People's Republic of China.
Parasit. Vectors 5 , 260, (2012) The application of chemical molluscicides is still one of the most effective measures for schistosomiasis control in P. R. China. By applying diverse molluscicide treatment scenarios on different snail densities in the field, we attempted to understand the co... |
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Detection of Taenia solium taeniasis coproantigen is an early indicator of treatment failure for taeniasis.
Clin. Vaccine Immunol. 19(4) , 570-3, (2012) Taenia solium causes taeniasis and cysticercosis, a zoonotic complex associated with a significant burden of epilepsy in most countries. Reliable diagnosis and efficacious treatment of taeniasis are needed for disease control. Currently, cure can be confirmed... |
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Multi-targeted therapy of cancer by niclosamide: A new application for an old drug.
Cancer Lett. 349(1) , 8-14, (2014) The rapid development of new anticancer drugs that are safe and effective is a common goal shared by basic scientists, clinicians and patients. The current review discusses one such agent, namely niclosamide, which has been used in the clinic for the treatmen... |