Flunarizine 2HCl
Flunarizine 2HCl structure
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Common Name | Flunarizine 2HCl | ||
|---|---|---|---|---|
| CAS Number | 30484-77-6 | Molecular Weight | 477.417 | |
| Density | N/A | Boiling Point | 511.3ºC at 760 mmHg | |
| Molecular Formula | C26H28Cl2F2N2 | Melting Point | 204-210ºC | |
| MSDS | Chinese USA | Flash Point | 263ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Propofol-induced pain sensation involves multiple mechanisms in sensory neurons.
Pflugers Arch. 467 , 2011-20, (2015) Propofol, a commonly used intravenous anesthetic agent, is known to at times cause pain sensation upon injection in humans. However, the molecular mechanisms underlying this effect are not fully understood. Although propofol was reported to activate human tra... |
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An in vivo antilymphatic screen in zebrafish identifies novel inhibitors of mammalian lymphangiogenesis and lymphatic-mediated metastasis.
Mol. Cancer Ther. 13(10) , 2450-62, (2014) The growth of new lymphatic vessels (lymphangiogenesis) in tumors is an integral step in the metastatic spread of tumor cells, first to the sentinel lymph nodes that surround the tumor and then elsewhere in the body. Currently, no selective agents designed to... |
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A high throughput screen identifies chemical modulators of the laminin-induced clustering of dystroglycan and aquaporin-4 in primary astrocytes.
PLoS ONE 6(3) , e17559, (2011) Aquaporin-4 (AQP4) constitutes the principal water channel in the brain and is clustered at the perivascular astrocyte endfeet. This specific distribution of AQP4 plays a major role in maintaining water homeostasis in the brain. A growing body of evidence poi... |
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Calcium antagonists as an add-on therapy for drug-resistant epilepsy.
Cochrane Database Syst. Rev. 3 , CD002750, (2013) This is an updated version of the original Cochrane review published in The Cochrane Library 2001, Issue 4.Nearly a third of people with epilepsy do not have their seizures controlled with current treatments. Continuous attempts have been made to find new ant... |
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In a nongenomic action, steroid hormone 20-hydroxyecdysone induces phosphorylation of cyclin-dependent kinase 10 to promote gene transcription.
Endocrinology 155(5) , 1738-50, (2014) The insect steroid hormone 20-hydroxyecdysone (20E) regulates gene transcription via a genomic pathway by forming a transcription complex that binds to DNA with the help of the chaperone proteins, heat shock proteins (Hsps) Hsc70 and Hsp90. However, the nonge... |
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Influence of calcium channel antagonists on nonsomatic signs of nicotine and D-amphetamine withdrawal in mice.
Pharmacol. Rep. 66(2) , 212-22, (2014) Nonsomatic signs of psychostimulant withdrawal, difficult to demonstrate in animal paradigms, may appear to promote drug seeking and drug relapse in humans; thus, it is important to understand the mechanisms that mediate this kind of behaviors. The present st... |
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Alternating hemiplegia of childhood: successful treatment with topiramate and flunarizine, a case report.
Ann. Trop. Paediatr. 31(2) , 149-52, (2011) Alternating hemiplegia of childhood (AHC) is a rare neurological disorder which usually presents before 18 months of age and is characterised by recurrent alternating episodes of hemiparesis. A single effective treatment for this condition is yet to be establ... |
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HOCl causes necrotic cell death in human monocyte derived macrophages through calcium dependent calpain activation.
Biochim. Biophys. Acta 1823(2) , 420-9, (2012) The abundance of dead macrophages in close proximity to HOCl-modified proteins in advanced atherosclerotic plaques implicates HOCl in the killing of macrophages and the formation of the necrotic core region. The mechanism of HOCl mediated death of macrophages... |
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Comparison of flunarizine and topiramate for the prophylaxis of pediatric migraines.
Eur. J. Paediatr. Neurol. 17(1) , 45-9, (2013) The purpose of this study was to compare the efficacy and tolerability of topiramate and flunarizine for the prophylaxis of pediatric migraines. A retrospective medical-record review of patients who underwent prophylaxis after receiving a diagnosis of migrain... |
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Effects of calcium channel antagonists on the motivational effects of nicotine and morphine in conditioned place aversion paradigm.
Behav. Brain Res. 228(1) , 144-50, (2012) The motivational component of drug withdrawal may contribute to drug seeking and relapse through the negative reinforcement-related process; thus, it is important to understand the mechanisms that mediate affective withdrawal behaviors. The present study was ... |