()-Eseroline fumarate salt
()-Eseroline fumarate salt structure
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Common Name | ()-Eseroline fumarate salt | ||
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| CAS Number | 70310-73-5 | Molecular Weight | 334.36700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H22N2O5 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Reversible inhibition of acetylcholinesterase by eseroline, an opioid agonist structurally related to physostigmine (eserine) and morphine.
Biochem. Pharmacol. 31 , 1233, (1982) The action of eseroline--(3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indo l-5-ol--salicylate was tested on preparations of ChE from different sources and on the longitudinal muscle of guinea-pig ileum. While eseroline is eseroline is extre... |
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Direct evidence that eseroline possesses morphine-like effects.
Eur. J. Pharmacol. 83 , 232, (1982) The opiate-like effects of eseroline, a physostigmine derivative, were studied in different tests. The antinociceptive effect of eseroline given s.c. and intracerebrally could be detected in the rat hot plate test and was reversed by naloxone. The apparent pA... |
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Eseroline, a metabolite of physostigmine, induces neuronal cell death.
Toxicol. Appl. Pharmacol. 106 , 28, (1990) The toxic effects of physostigmine, an anticholinesterase drug, and its metabolite eseroline were investigated in three neuronal cell culture systems, mouse neuroblastoma N1E-115, rat glioma C6, and neuroblastoma-glioma hybrid NG 108-15. Physostigmine and ese... |
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In-vitro and in-vivo protection of acetylcholinesterase by eseroline against inactivation by diisopropyl fluorophosphate and carbamates.
J. Pharm. Pharmacol. 37 , 42, (1985) The protective action of eseroline--(3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3 a, 8-trimethyl-pyrrolo[2,3-b]indol-5-ol--salicylate against (DFP) diisopropyl fluorophosphate and carbamate poisoning of cholinesterases (ChEs) has been examined in-vitro with human ery... |