DC Chemicals Limited
China
Product Name: (-)-Eseroline fumarate
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

70310-73-5

70310-73-5 structure

Name: ()-Eseroline fumarate salt
Chemical Name: (3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-ol,(E)-but-2-enedioic acid
CAS Number: 70310-73-5
Molecular Formula: C₁₇H₂₂N₂O₅
Molecular Weight: 334.36700
Catalog: analytical chemistry Standard Forensic and veterinary standards
Create Date: 2017-12-09 07:58:59
Modify Date: 2024-01-13 19:39:53
(-)-Eseroline fumarate is a metabolic of Physostigmine (HY-N6608), an AChE inhibitor. (-)-Eseroline fumarate elicits a leakage of lactic acid dehydrogenase (LDH) from cancer cells. (-)-Eseroline fumarate also induces the release of adenine nucleotides and 5-hydroxytryptamine (5-HT) from neuronal cells, thus induce cell death. (-)-Eseroline fumarate inhibits the electrically evoked twitches of the mouse vas deferens and of the guinea-pig ileum[1][2].

Name	(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-ol,(E)-but-2-enedioic acid
Synonyms	(-)-Eseroline fumarate salt (u2212)-Eseroline fumarate salt E100_FLUKA

Description	(-)-Eseroline fumarate is a metabolic of Physostigmine (HY-N6608), an AChE inhibitor. (-)-Eseroline fumarate elicits a leakage of lactic acid dehydrogenase (LDH) from cancer cells. (-)-Eseroline fumarate also induces the release of adenine nucleotides and 5-hydroxytryptamine (5-HT) from neuronal cells, thus induce cell death. (-)-Eseroline fumarate inhibits the electrically evoked twitches of the mouse vas deferens and of the guinea-pig ileum[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
In Vitro	(-)-Eseroline fumarate (0.5 mM; 0-25 hr) 时间依赖性地诱导小鼠神经母细胞瘤 N1E-115、大鼠胶质瘤 C6 和神经母细胞癌-胶质瘤杂交 NG 108-15 中的 LDH 泄露[1]。
In Vivo	(-)-Eseroline fumarate (盐酸; 10 mg/kg; 静脉注射; 单剂量) 诱导成年杂种猫的大脑皮层释放5-HT[2]。 (-)-Eseroline fumarate (水杨酸; 9 mg/kg; 皮下注射; 单剂量) 在小鼠甩尾试验中显示出镇痛的作用，并强烈地降低 Physostigmine (HY-N6608) 的抗伤害作用[3]。
References	[1]. Somani SM, et al. Eseroline, a metabolite of physostigmine, induces neuronal cell death. Toxicol Appl Pharmacol. 1990 Oct;106(1):28-37. [2]. Bartolini A, et al. Eseroline: a new antinociceptive agent derived from physostigmine with opiate receptor agonist properties. Experimental in vivo and in vitro studies on cats and rodents. Neurosci Lett. 1981 Sep 1;25(2):179-83. [3]. Harris LS, et al. Narcotic-antagonist analgesics: interactions with cholinergic systems. J Pharmacol Exp Ther. 1969 Sep;169(1):17-22.

Molecular Formula	C₁₇H₂₂N₂O₅
Molecular Weight	334.36700
Exact Mass	334.15300
PSA	101.31000
LogP	1.47600
Appearance	white
Storage condition	2-8°C
Water Solubility	0.1 M HCl: soluble (Solutions should be freshly prepared.)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

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