8-Bromo-AMP
8-Bromo-AMP structure
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Common Name | 8-Bromo-AMP | ||
|---|---|---|---|---|
| CAS Number | 23567-96-6 | Molecular Weight | 424.10100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H11BrN5O7P | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Recipient pretransplant inosine monophosphate dehydrogenase activity in nonmyeloablative hematopoietic cell transplantation.
Biol. Blood Marrow Transplant. 20(10) , 1544-52, (2014) Mycophenolic acid, the active metabolite of mycophenolate mofetil (MMF), inhibits inosine monophosphate dehydrogenase (IMPDH) activity. IMPDH is the rate-limiting enzyme involved in de novo synthesis of guanosine nucleotides and catalyzes the oxidation of ino... |
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Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production.
Reprod. Biol. Endocrinol. 6 , 62, (2009) P450 oxidoreductase (POR) catalyzes electron transfer to microsomal P450 enzymes. Its deficiency causes Antley-Bixler syndrome (ABS), and about half the patients with ABS have ambiguous genitalia and/or impaired steroidogenesis. POR mRNA expression is up-regu... |
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Tonically Active cAMP-Dependent Signaling in the Ventrolateral Medulla Regulates Sympathetic and Cardiac Vagal Outflows.
J. Pharmacol. Exp. Ther. 356 , 424-33, (2016) The ventrolateral medulla contains presympathetic and vagal preganglionic neurons that control vasomotor and cardiac vagal tone, respectively. G protein-coupled receptors influence the activity of these neurons. Gα s activates adenylyl cyclases, which drive c... |
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Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos.
PLoS ONE 7 , e41424, (2012) The aetiology of recurrent miscarriage (RM) remains largely unexplained. Women with RM have a shorter time to pregnancy interval than normally fertile women, which may be due to more frequent implantation of non-viable embryos. We hypothesized that human endo... |
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Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation.
PLoS ONE 5 , e10258, (2010) Pregnancy is widely viewed as dependent upon an intimate dialogue, mediated by locally secreted factors between a developmentally competent embryo and a receptive endometrium. Reproductive success in humans is however limited, largely because of the high prev... |
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Cell lineage specific distribution of H3K27 trimethylation accumulation in an in vitro model for human implantation.
PLoS ONE 7 , e32701, (2012) Female mammals inactivate one of their two X-chromosomes to compensate for the difference in gene-dosage with males that have just one X-chromosome. X-chromosome inactivation is initiated by the expression of the non-coding RNA Xist, which coats the X-chromos... |
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Schwann cell-free adult canine olfactory ensheathing cell preparations from olfactory bulb and mucosa display differential migratory and neurite growth-promoting properties in vitro.
BMC Neurosci. 14 , 141, (2014) Transplantation of olfactory ensheathing cells (OEC) and Schwann cells (SC) is a promising therapeutic strategy to promote axonal growth and remyelination after spinal cord injury. Previous studies mainly focused on the rat model though results from primate a... |
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Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway.
PLoS ONE 6(11) , e27586, (2011) Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue microenvironments are often acidic at inflammatory sites, the mechanisms by which cells respond to acidosis are not well understood. Using molecular, cellular and bio... |
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Synthesis and protective effects of poly-8-bromoriboadenylic acid: poly ribouridylic acid hybrid against Wesselsbron virus in chick embryos.
J. Biochem. 96 , 1297-1301, (1984) Poly-8-bromoriboadenylic acid was synthesized by the bromination of adenosine-5'-monophosphate to yield 8-bromoadenosine-5'-monophosphate which on conversion to the 5'-diphosphate form was polymerized by polynucleotide phosphorylase (PNPase). The polymer form... |
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K+ channel regulator KCR1 suppresses heart rhythm by modulating the pacemaker current If.
PLoS ONE 3 , e1511, (2008) Hyperpolarization-activated, cyclic nucleotide sensitive (HCN) channels underlie the pacemaker current I(f), which plays an essential role in spontaneous cardiac activity. HCN channel subunits (HCN1-4) are believed to be modulated by additional regulatory pro... |