2-DEOXY-ALPHA-D-RIBOSE 1-PHOSPHATE BIS(CYCLOHEXYLAMINE) SALT
2-DEOXY-ALPHA-D-RIBOSE 1-PHOSPHATE BIS(CYCLOHEXYLAMINE) SALT structure
|
Common Name | 2-DEOXY-ALPHA-D-RIBOSE 1-PHOSPHATE BIS(CYCLOHEXYLAMINE) SALT | ||
|---|---|---|---|---|
| CAS Number | 102783-28-8 | Molecular Weight | 412.45900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H37N2O7P | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
|
The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression.
Cancer Sci. 95(11) , 851-7, (2004) Thymidine phosphorylase (TP), an enzyme involved in pyrimidine metabolism, is identical with an angiogenic factor, platelet-derived endothelial cell growth factor (PD-ECGF). TP is overexpressed in various tumors and plays an important role in angiogenesis, tu... |
|
|
The kinetic mechanism of Human Thymidine Phosphorylase - a molecular target for cancer drug development.
Mol. Biosyst. 10(3) , 592-604, (2014) Human Thymidine Phosphorylase (HTP), also known as the platelet-derived endothelial cell growth factor (PD-ECGF) or gliostatin, catalyzes the reversible phosphorolysis of thymidine (dThd) to thymine and 2-deoxy-α-d-ribose-1-phosphate (2dR1P). HTP is a key enz... |
|
|
Efficient chemo-enzymatic syntheses of pharmaceutically useful unnatural 2'-deoxynucleosides.
Nucleosides Nucleotides Nucleic Acids 24(5-7) , 1127-30, (2005) Our chemo-enzymatic method was successfully applied to the synthesis of 2-chloro-2'-deoxyadenosine (CdA, cladribine) in two ways: 1) direct conversion of chemically synthesized 2-deoxy-alpha-D-ribose 1-phosphate (dRP) to CdA; 2) a two-step route via 9-(2-deox... |
|
|
Autocrine amplification of integrin αIIbβ3 activation and platelet adhesive responses by deoxyribose-1-phosphate.
Thromb. Haemost. 109(6) , 1108-19, (2013) Using direct injection mass spectrometry (DIMS) we discovered that deoxyribose-1-phosphate (dRP) is released by platelets upon activation. Interestingly, the addition of exogenous dRP to human platelets significantly increased platelet aggregation and integri... |