Indeno[1,2,3-gh]tetraphene
![Indeno[1,2,3-gh]tetraphene Structure](https://image.chemsrc.com/caspic/052/5385-75-1.png)
Indeno[1,2,3-gh]tetraphene structure
|
Common Name | Indeno[1,2,3-gh]tetraphene | ||
|---|---|---|---|---|
| CAS Number | 5385-75-1 | Molecular Weight | 302.368 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 552.3±17.0 °C at 760 mmHg | |
| Molecular Formula | C24H14 | Melting Point | 232ºC | |
| MSDS | USA | Flash Point | 282.0±15.1 °C | |
| Symbol |
GHS08 |
Signal Word | Warning | |
|
Differences in metabolic activation of dibenzo[a,e]fluoranthene characterized by 32P-postlabeling in two mouse fibroblast models.
Cancer Lett. 61(3) , 207-13, (1992) The formation of DNA adducts was investigated in mouse fibroblasts from two different tissues--embryos and adult lung--after incubation with dibenzo[a,e]fluoranthene (DBF) or its major proximate metabolites. The nuclease P1 modification of the 32P-postlabelin... |
|
|
Dibenzo[a,e]fluoranthene.
IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 32 , 321-5, (1983)
|
|
|
Metabolic activation of dibenzo(a,e)fluoranthene, a nonalternant carcinogenic polycyclic hydrocarbon, in liver homogenates.
Cancer Res. 40(5) , 1742-9, (1980)
|
|
|
Apparent stimulation of dibenzo[a,e]fluoranthene in vitro metabolism in the presence of norharman.
Chem. Biol. Interact. 37(1-2) , 109-22, (1981) The effects of norharman (NH) on the metabolism of dibenzo[a,e]-fluoranthene (DBF) and on its fixation on DNA, RNA and proteins have been studied in vitro by incubation with S-9 and microsomes from rats and mice. NH causes a decrease of the activity of micros... |
|
|
DNA-protein crosslinks induced by exposure of cultured mouse fibroblasts to dibenzo[a,e]fluoranthene and its bay- and pseudo-bay region dihydrodiols.
Carcinogenesis 5(3) , 379-83, (1984) The presence of DNA-protein crosslinks was shown by the alkaline elution technique in cultured mouse fibroblasts treated with dibenzo[a,e]fluoranthene (DBF), a non-alternating carcinogenic PAH. The crosslinks appeared to be between DNA and protein, since the ... |
|
|
Multi-step metabolism of the carcinogen dibenzo[a,e]fluoranthene. I. Identification of the metabolites from rat microsomes.
Carcinogenesis 4(7) , 827-35, (1983) The metabolism of the polycyclic hydrocarbon dibenzo[a,e]fluoranthene (DBF) has been investigated. Two new primary metabolites have been identified by proton n.m.r. as the trans diaxial dihydrodiols of the bay and of the pseudo bay regions of DBF. In addition... |
|
|
Marked differences between mutagenicity in Salmonella and tumour-initiating activities of dibenzo[a,e]fluoranthene proximate metabolites; initiation inhibiting activity of norharman.
Carcinogenesis 8(3) , 461-4, (1987) Dibenzofluoranthene-12,13-dihydrodiol (DBF-12,13-DHD) is six times more mutagenic in Salmonella TA100 than dibenzofluoranthene-3,4-dihydrodiol (DBF-3,4-DHD). However, these two major dibenzo[a,e]fluoranthene (DBF) proximate metabolites, which are immediate pr... |
|
|
Binding to DNA of bay region and pseudo bay region diol-epoxides of dibenzo[a,e]fluoranthene and comparison with adducts obtained with dibenzo[a,e]fluoranthene or its dihydrodiols in the presence of microsomes.
Carcinogenesis 4(1) , 27-32, (1983) When dibenzo[a,e]fluoranthene (DBF) is incubated in vitro with mouse liver microsomes in the presence of calf thymus DNA, several metabolites bind covalently to DNA. The metabolite-nucleoside adducts were separated by h.p.l.c. after enzymatic hydrolysis. The ... |
|
|
Formation and removal of dibenzo[a,e]fluoranthene-DNA adducts in mouse embryo fibroblasts.
Carcinogenesis 6(12) , 1791-6, (1985) In vivo binding of dibenzo[a,e]fluoranthene (DBF) to mouse embryo fibroblast DNA was compared with that observed previously in vitro on calf thymus DNA incubated with mouse liver microsomes. The h.p.l.c. elution patterns of the adducts formed by DBF metabolit... |
|
|
Possible involvement of a vicinal, non-bay-region dihydrodiol-epoxide in the activation of dibenzo[a,e]fluoranthene into bacterial mutagens.
Carcinogenesis 5(10) , 1263-6, (1984) Dibenzo[a,e]fluoranthene, its 7-hydroxy, 3,4- and 12,13-dihydrodiol metabolic derivatives as well as three synthetic, structurally related hydrocarbons, were tested for mutagenicity towards Salmonella typhimurium TA100 strain in the presence of 3-methylcholan... |