ALPHA-THYMIDINE
ALPHA-THYMIDINE structure
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Common Name | ALPHA-THYMIDINE | ||
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| CAS Number | 4449-43-8 | Molecular Weight | 242.22900 | |
| Density | 1.452g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C10H14N2O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase
Bioorg. Med. Chem. 19(24) , 7603-1, (2011) We report on Mycobacterium tuberculosis thymidine monophosphate kinase (TMPKmt) inhibitory activities of a series of new 3'- and 5'-modified thymidine analogues including α- and β-derivatives. In addition, several analogues were synthesized in which the 4-oxy... |
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Rational design and 3D-pharmacophore mapping of 5'-thiourea-substituted alpha-thymidine analogues as mycobacterial TMPK inhibitors.
J. Chem. Inf. Model. 49 , 1070-1078, (2009) Thymidine monophosphate kinase (TMPK) has emerged as an attractive target for developing inhibitors of Mycobacterium tuberculosis growth. In this study the receptor-independent (RI) 4D-QSAR formalism has been used to develop QSAR models and corresponding 3D-p... |
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Chemical synthesis of hydroxymethylphosphonate alpha-DNA.
Nucleic Acids Symp. Ser. 44 , 31-32, (2000) In this paper, we report the synthesis of hydroxymethylphosphonate alpha-DNAs and related compounds by use of the H-phosphonate method. These modified alpha-DNAs were designed to improve the inherent poor solubility of well-known methylphosphonate alpha-DNAs ... |