BTA-1
BTA-1 structure
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Common Name | BTA-1 | ||
|---|---|---|---|---|
| CAS Number | 439858-28-3 | Molecular Weight | 240.32300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H12N2S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques.
Nat. Commun. 6 , 6176, (2015) In Alzheimer's disease (AD), β-amyloid (Aβ) plaques are tightly enveloped by microglia processes, but the significance of this phenomenon is unknown. Here we show that microglia constitute a barrier with profound impact on plaque composition and toxicity. Usi... |
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The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component.
J. Neurosci. 23 , 2086-2092, (2003) 2-(4'-methylaminophenyl)benzothiazole (BTA-1) is an uncharged derivative of thioflavin-T that has high affinity for Abeta fibrils and shows very good brain entry and clearance. In this study, we asked whether BTA-1, at concentrations typical of those achieved... |
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A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.
Bioorg. Med. Chem. Lett. 12 , 295-298, (2002) The synthesis of a new lipophilic thioflavin-T analogue (2-[4' -(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [(11)C]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were i... |
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Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain.
Life Sci. 69 , 1471-1484, (2001) In vivo assessment of the beta-sheet proteins deposited in amyloid plaques (A beta peptide) or neurofibrillary tangles (tau protein) presents a target for the development of biological markers for Alzheimer's disease (AD). In an effort to develop in vivo beta... |
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Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study.
Eur. J. Nucl. Med. Mol. Imaging 42 , 1119-32, (2015) Pathological studies suggest that neuroinflammation is exacerbated by increased beta-amyloid (Aβ) levels in the brain early in Alzheimer's disease (AD). The time course and relationships between astrocytosis and Aβ deposition were examined using multitracer i... |
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Optical visualization of Alzheimer's pathology via multiphoton-excited intrinsic fluorescence and second harmonic generation.
Opt. Express 17 , 3679-89, (2010) Intrinsic optical emissions, such as autofluorescence and second harmonic generation (SHG), are potentially useful for functional fluorescence imaging and biomedical disease diagnosis for neurodegenerative diseases such as Alzheimer's disease (AD). Here, usin... |