BTA-1
BTA-1 structure
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Common Name | BTA-1 | ||
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| CAS Number | 439858-28-3 | Molecular Weight | 240.32300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H12N2S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of BTA-1BTA-1 is an uncharged derivative of thioflavin-T. BTA-1 has high affinity for Aβ fibrils and shows very good brain entry and clearance[1]. |
| Name | 4-(1,3-benzothiazol-2-yl)-N-methylaniline |
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| Synonym | More Synonyms |
| Description | BTA-1 is an uncharged derivative of thioflavin-T. BTA-1 has high affinity for Aβ fibrils and shows very good brain entry and clearance[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C14H12N2S |
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| Molecular Weight | 240.32300 |
| Exact Mass | 240.07200 |
| PSA | 53.16000 |
| LogP | 4.07800 |
| Storage condition | 2-8℃ |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2934200090 |
| HS Code | 2934200090 |
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| Summary | 2934200090. other compounds containing in the structure a benzothiazole ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques.
Nat. Commun. 6 , 6176, (2015) In Alzheimer's disease (AD), β-amyloid (Aβ) plaques are tightly enveloped by microglia processes, but the significance of this phenomenon is unknown. Here we show that microglia constitute a barrier w... |
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The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component.
J. Neurosci. 23 , 2086-2092, (2003) 2-(4'-methylaminophenyl)benzothiazole (BTA-1) is an uncharged derivative of thioflavin-T that has high affinity for Abeta fibrils and shows very good brain entry and clearance. In this study, we asked... |
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A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.
Bioorg. Med. Chem. Lett. 12 , 295-298, (2002) The synthesis of a new lipophilic thioflavin-T analogue (2-[4' -(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [(11)C]-labeled 6 in control ... |
| 2-(4'-Methylaminophenyl)benzothiazole |
| BTA-1 |
| Benzo-Thiazole-Aniline-1-Methyl |