zopiclone n-oxide
zopiclone n-oxide structure
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Common Name | zopiclone n-oxide | ||
|---|---|---|---|---|
| CAS Number | 43200-96-0 | Molecular Weight | 404.80800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H17ClN6O4 | Melting Point | >140ºC (dec.) | |
| MSDS | N/A | Flash Point | 9℃ | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Determination of the enantiomers of zopiclone and its two chiral metabolites in urine using an automated coupled achiral-chiral chromatographic system.
J. Chromatogr. A. 617(2) , 271-8, (1993) The enantiomers of zopiclone and its two chiral N-desmethyl and N-oxide metabolites were determined in urine using a coupled achiral-chiral liquid chromatographic method. After liquid-liquid extraction, zopiclone and its two metabolites were quantified on a c... |
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Capillary electrophoretic enantioselective determination of zopiclone and its impurities.
Electrophoresis 33(11) , 1606-12, (2012) A capillary electrophoretic enantioselective method with UV detection was developed and validated for the simultaneous quantification of zopiclone enantiomers and its impurities, zopiclone-N-oxide enantiomers, and 2-amino-5-chloropyridine, in tablets. The ana... |
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Simultaneous determination of zopiclone and its two major metabolites (N-oxide and N-desmethyl) in human biological fluids by reversed-phase high-performance liquid chromatography.
J. Chromatogr. A. 417(1) , 151-8, (1987) A high-performance liquid chromatographic method has been developed for the simultaneous determination of zopiclone and its main metabolites (N-oxide and N-desmethyl derivatives) in biological fluids. After selective extraction (dichloromethane-2-propanol) th... |
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Pharmacokinetics of zopiclone and its enantiomers in Caucasian young healthy volunteers.
Drug Metab. Dispos. 21(6) , 1125-8, (1993) The disposition of the enantiomers of zopiclone and its two chiral metabolites was investigated after oral administration of a single dose of 15 mg of a racemic mixture (twice the usual therapeutic regimen) in 12 adult Caucasian volunteers. Determination of c... |
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Two cases of methemoglobinemia following zopiclone ingestion.
Clin. Toxicol. (Phila.) 46(2) , 167-70, (2008) Most cases of methemoglobinemia result from exposure to certain medications and chemicals such as nitrates, nitrites, aniline, dapsone, phenazopyridine, benzocaine, and chlorates which oxidize the iron from the ferrous state. Intoxication with zopiclone is ex... |
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HPLC-ESI-MS/MS validated method for simultaneous quantification of zopiclone and its metabolites, N-desmethyl zopiclone and zopiclone-N-oxide in human plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 864(1-2) , 137-48, (2008) A simple, selective and sensitive isocratic HPLC method with triple quadrupole mass spectrometry detection has been developed and validated for simultaneous quantification of zopiclone and its metabolites in human plasma. The analytes were extracted using sol... |