thieno(2,3-c)isoquinolin-5-one
thieno(2,3-c)isoquinolin-5-one structure
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Common Name | thieno(2,3-c)isoquinolin-5-one | ||
|---|---|---|---|---|
| CAS Number | 420849-22-5 | Molecular Weight | 201.244 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 282.2±9.0 °C at 760 mmHg | |
| Molecular Formula | C11H7NOS | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 124.5±18.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Poly(ADP-ribose) polymerase-1 inhibition prevents eosinophil recruitment by modulating Th2 cytokines in a murine model of allergic airway inflammation: a potential specific effect on IL-5.
J. Immunol. 177(9) , 6489-96, (2006) We recently used a murine model of allergic airway inflammation to show that poly(ADP-ribose) polymerase-1 (PARP-1) plays an important role in the pathogenesis of asthma-related lung inflammation. In this study, we show that PARP-1 inhibition, by a novel inhi... |
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Thieno[2,3-c]isoquinolin-5-one, a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-deficient mice: effects on inflammatory markers and lipid content.
J. Pharmacol. Exp. Ther. 329(1) , 150-8, (2009) We recently showed that poly(ADP-ribose) polymerase (PARP) is activated within atherosclerotic plaques in an animal model of atherosclerosis. Pharmacological inhibition of PARP or reduced expression in heterozygous animals interferes with atherogenesis and ma... |
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