(S)-N-t-butyl decahydro-3-iso-quinolinecarboxamide

(S)-N-t-butyl decahydro-3-iso-quinolinecarboxamide Structure
(S)-N-t-butyl decahydro-3-iso-quinolinecarboxamide structure
Common Name (S)-N-t-butyl decahydro-3-iso-quinolinecarboxamide
CAS Number 136465-81-1 Molecular Weight 238.369
Density 1.0±0.1 g/cm3 Boiling Point 401.5±24.0 °C at 760 mmHg
Molecular Formula C14H26N2O Melting Point 112-115ºC
MSDS Chinese USA Flash Point 146.7±23.0 °C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity.

J. Med. Chem. 35 , 2525, (1992)

A series of HIV-1 protease inhibitors containing a novel hydroxyethyl secondary amine transition state isostere has been synthesized. The compounds exhibit a strong preference for the (R) stereochemistry at the transition state hydroxyl group. Molecular model...

Trova, M.P. et al.

Bioorg. Med. Chem. Lett. 3 , 1595, (1993)