Hexadimethrine bromide
Hexadimethrine bromide structure
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Common Name | Hexadimethrine bromide | ||
|---|---|---|---|---|
| CAS Number | 28728-55-4 | Molecular Weight | 404.27 | |
| Density | N/A | Boiling Point | 209.5ºC at 760 mmHg | |
| Molecular Formula | C15H36Br2N2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 73.9ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis.
Cell Death Dis. 6 , e1841, (2015) Dual specificity protein phosphatase 26 (DUSP26) is overexpressed in high-risk neuroblastoma (NB) and contributes to chemoresistance by inhibiting p53 function. In vitro, DUSP26 has also been shown to effectively inhibit p38 MAP kinase. We hypothesize that in... |
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Polyomavirus T antigens activate an antiviral state.
Virology 476 , 377-85, (2015) Ectopic expression of Simian Virus 40 (SV40) large T antigen (LT) in mouse embryonic fibroblasts (MEFs) increased levels of mRNAs encoding interferon stimulated genes (ISGs). The mechanism by which T antigen increases levels of ISGs in MEFs remains unclear. W... |
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Polybrene: Observations on cochlear hair cell necrosis and minimal lentiviral transduction of cochlear hair cells.
Neurosci. Lett. 600 , 164-70, (2015) Polybrene is widely used to enhance viral transduction; however, little is known about the utility thereof, in enhancing lentiviral transduction of cochlear cells. In the present study, we examined the cytotoxic effects of polybrene, and the further effects t... |
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Circovirus transport proceeds via direct interaction of the cytoplasmic dynein IC1 subunit with the viral capsid protein.
J. Virol. 89(5) , 2777-91, (2015) Microtubule transport of circovirus from the periphery of the cell to the nucleus is essential for viral replication in early infection. How the microtubule is recruited to the viral cargo remains unclear. In this study, we observed that circovirus traffickin... |
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Defects in calcium homeostasis and mitochondria can be reversed in Pompe disease.
Autophagy 11(2) , 385-402, (2015) Mitochondria-induced oxidative stress and flawed autophagy are common features of neurodegenerative and lysosomal storage diseases (LSDs). Although defective autophagy is particularly prominent in Pompe disease, mitochondrial function has escaped examination ... |
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Tetraspanin CD9 regulates cell contraction and actin arrangement via RhoA in human vascular smooth muscle cells.
PLoS ONE 9(9) , e106999, (2014) The most prevalent cardiovascular diseases arise from alterations in vascular smooth muscle cell (VSMC) morphology and function. Tetraspanin CD9 has been previously implicated in regulating vascular pathologies; however, insight into how CD9 may regulate adve... |
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MAZR and Runx Factors Synergistically Repress ThPOK during CD8+ T Cell Lineage Development.
J. Immunol. 195 , 2879-87, (2015) Th-inducing Pox virus and zinc finger/Krüppel-like factor (ThPOK) is a key commitment factor for CD4(+) lineage T cells and is essential for the maintenance of CD4 lineage integrity; thus, the expression of ThPOK has to be tightly controlled. In this article,... |
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Anoctamin 1 calcium-activated chloride channel downregulates estrogen production in mouse ovarian granulosa cells.
Endocrinology 155(8) , 2787-96, (2014) Calcium-dependent chloride conductances have been described in chicken and human granulosa cells (GCs) and may be involved in steroidogenesis. However, the molecular identities of corresponding chloride channels remain unknown. The purpose of this study was t... |
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A bacterial type III secretion-based protein delivery tool for broad applications in cell biology.
J. Cell Biol. 211 , 913-31, (2015) Methods enabling the delivery of proteins into eukaryotic cells are essential to address protein functions. Here we propose broad applications to cell biology for a protein delivery tool based on bacterial type III secretion (T3S). We show that bacterial, vir... |
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Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines.
PLoS ONE 10 , e0131467, (2015) Retinoids have been shown to serve promising therapeutic agents for human cancers, e.g. the treatment of neuroblastoma. Synthetic retinoids, specific for particular retinoic acid (RA) receptors, are tested as new therapy strategies. In the present study, appl... |