N-[(1R)-1-(Hydroxydiphenylmethyl)-3-methylbutyl]-D-prolinamide

N-[(1R)-1-(Hydroxydiphenylmethyl)-3-methylbutyl]-D-prolinamide Structure
N-[(1R)-1-(Hydroxydiphenylmethyl)-3-methylbutyl]-D-prolinamide structure
Common Name N-[(1R)-1-(Hydroxydiphenylmethyl)-3-methylbutyl]-D-prolinamide
CAS Number 1088110-92-2 Molecular Weight 366.5
Density N/A Boiling Point N/A
Molecular Formula C23H30N2O2 Melting Point 194°C±3°C
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

Highly enantioselective direct aldol reaction catalyzed by organic molecules.

Org. Lett. 8 , 4097-4099, (2006)

We have demonstrated that a new class of l-proline-based organic compounds catalyzed the direct aldol reaction between aldehydes and acetone to provide beta-hydroxy ketones in good yields. The reaction is efficient, and 5-10 mol % of the catalyst and excellen...

Direction of Kinetically versus Thermodynamically Controlled Organocatalysis and Its Application in Chemoenzymatic Synthesis Rulli, G., et al.

Angew. Chem. Int. Ed. Engl. 50 , 1-5, (2011)