R-MVA-Li
R-MVA-Li structure
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Common Name | R-MVA-Li | ||
|---|---|---|---|---|
| CAS Number | 1255502-07-8 | Molecular Weight | 154.09 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C6H11LiO4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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An ultrasensitive enzymatic method for measuring mevalonic acid in serum.
J. Lipid Res. 53 , 1987-1992, (2012) We have developed a simple, precise, and ultrasensitive enzymatic method for measuring serum mevalonic acid (MVA) concentration, which is thought to be a good indicator of the in vivo cholesterol biosynthesis rate. This assay is based on an enzyme cycling rea... |
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Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation.
Cell. Mol. Life Sci. 60 , 1118-1134, (2003) Mevalonate kinase (MK) is an essential enzyme in the isoprenoid biosynthesis pathway which produces numerous biomolecules (isoprenoids) involved in a variety of cellular processes. The indispensability of MK and isoprenoid biosynthesis for human health is dem... |
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Mevalonic aciduria--an inborn error of cholesterol and nonsterol isoprene biosynthesis.
N. Engl. J. Med. 314 , 1610-1614, (1986) A two-year-old boy presented with severe failure to thrive, developmental delay, anemia, hepatosplenomegaly, central cataracts, and dysmorphic features. Quantitative analyses of urinary organic acids revealed massive excretion of mevalonic acid, a metabolic p... |
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Mevalonate pathway: a review of clinical and therapeutical implications.
Clin. Biochem. 40 , 575-584, (2007) Mevalonate pathway is an important metabolic pathway which plays a key role in multiple cellular processes by synthesizing sterol isoprenoids, such as cholesterol, and non-sterol isoprenoids, such as dolichol, heme-A, isopentenyl tRNA and ubiquinone. While ex... |
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Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome.
Orphanet J. Rare Dis. 1 , 13, (2006) Mevalonic aciduria (MVA) and hyperimmunoglobulinemia D syndrome (HIDS) represent the two ends of a clinical spectrum of disease caused by deficiency of mevalonate kinase (MVK), the first committed enzyme of cholesterol biosynthesis. At least 30 patients with ... |
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(R)-mevalonate excretion in human and rat urines.
Proc. Natl. Acad. Sci. U. S. A. 77 , 5738-5740, (1980) (R)-Mevalonate was identified by radioenzymatic assay in human and rat urines. This was confirmed by spectrophotometric enzymatic assay of an ether extract of human urine. The average excretion rate of (R)-mevalonate in humans was 1.7 mumol/24 hr which corres... |
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Plasma mevalonate concentrations in uremic patients.
Kidney Int. 51 , 908-912, (1997) Mevalonic acid (mevalonate or MVA), is an obligate precursor in the biosynthetic pathway of cholesterol. It is partially metabolized by the kidneys and its plasma concentrations are an index of endogenous cholesterol synthesis. The aim of the present study wa... |
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Specific increase in caspase-1 activity and secretion of IL-1 family cytokines: a putative link between mevalonate kinase deficiency and inflammation.
Eur. Cytokine Netw. 20 , 101-107, (2009) The mevalonate kinase deficiency (MKD), including hyperimmunoglobulinemia D periodic fever syndrome (HIDS) and the more severe mevalonic aciduria are rare, autosomal recessive, autoinflammatory diseases belonging to the hereditary periodic fever (HPF) family.... |
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Characterization of a feedback-resistant mevalonate kinase from the archaeon Methanosarcina mazei.
Appl. Environ. Microbiol. 77 , 7772-7778, (2011) The mevalonate pathway is utilized for the biosynthesis of isoprenoids in many bacterial, eukaryotic, and archaeal organisms. Based on previous reports of its feedback inhibition, mevalonate kinase (MVK) may play an important regulatory role in the biosynthes... |
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The effect of clodronate on a mevalonate kinase deficiency cellular model.
Inflamm. Res. 61 , 1363-1367, (2012) A potential anti-inflammatory effect of clodronate--an aminobisphosphonate--was described to antagonize the pro-inflammatory effects of the block in the mevalonate pathway, the main feature of a rare auto-inflammatory disease called mevalonate kinase deficien... |