bupropion hydrochloride
bupropion hydrochloride structure
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Common Name | bupropion hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 31677-93-7 | Molecular Weight | 276.202 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H19Cl2NO | Melting Point | 233-234 °C | |
| MSDS | Chinese USA | Flash Point | 48.2 °F | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Phenotyping of CYP450 in human liver microsomes using the cocktail approach.
Anal. Bioanal. Chem 406(20) , 4875-87, (2014) The cocktail approach is an advantageous strategy used to monitor the activities of several cytochromes P450 (CYPs) in a single test to increase the throughput of in vitro phenotyping studies. In this study, a cocktail mixture was developed with eight CYP-spe... |
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Comparison of liquid chromatography and supercritical fluid chromatography coupled to compact single quadrupole mass spectrometer for targeted in vitro metabolism assay.
J. Chromatogr. A. 1371 , 244-56, (2014) The goal of this study was to evaluate the combination of powerful chromatographic methods and compact single quadrupole MS device for simple in vitro cytochrome P450 (CYP) inhibition assay, instead of more expensive triple quadrupole MS/MS detectors. For thi... |
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Delamanid does not inhibit or induce cytochrome p450 enzymes in vitro.
Biol. Pharm. Bull. 37(11) , 1727-35, (2014) Delamanid is a new drug for the treatment of multidrug-resistant tuberculosis. Individuals who are co-infected with human immunodeficiency virus and Mycobacterium tuberculosis may require treatment with a number of medications that might interact significantl... |
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SSRI versus bupropion effects on symptom clusters in suicidal depression: post hoc analysis of a randomized clinical trial.
J. Clin. Psychiatry 74(9) , 872-9, (2013) Identifying the depression symptoms most closely associated with suicidal thoughts and which medications provide the fastest depression relief may help suicide prevention.Post hoc analysis of data from a randomized, double-blind, 8-week clinical trial of the ... |
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Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disease and pharmacological rescuing of non-motor deficits.
Molecular Neurodegeneration 8 , 14, (2013) Parkinson's disease (PD) is a chronic neurodegenerative condition that is characterized by motor symptoms as a result of dopaminergic degeneration, particularly in the mesostriatal pathway. However, in recent years, a greater number of clinical studies have f... |
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Involvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients from herbal medicines.
Xenobiotica 45 , 773-81, (2015) 1. Induction of hepatic drug-metabolizing enzymes can affect drug efficacy and cause toxicity. However, so far, limited information is available regarding the molecular mechanism how herbal medicines induce human CYP2B6, which metabolizes many of the clinical... |
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Determination and validation of psammaplin A and its derivatives in rat plasma by liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic study.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1000 , 155-62, (2015) A liquid chromatography-tandem mass (LC-MS/MS) method was developed for the determination of psammaplin A (PsA) and its newly synthesized derivatives (PsA 107, PsA 109, and PsA 123) in rat plasma using bupropion as an internal standard (IS). The plasma sample... |
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D1 and D2 antagonists reverse the effects of appetite suppressants on weight loss, food intake, locomotion, and rebalance spiking inhibition in the rat NAc shell.
J. Neurophysiol. 114 , 585-607, (2015) Obesity is a worldwide health problem that has reached epidemic proportions. To ameliorate this problem, one approach is the use of appetite suppressants. These compounds are frequently amphetamine congeners such as diethylpropion (DEP), phentermine (PHEN), a... |
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The influence of caffeine on the activity of moclobemide, venlafaxine, bupropion and milnacipran in the forced swim test in mice.
Life Sci. 136 , 13-8, (2015) Worrying data indicate that excessive caffeine intake applies to patients suffering from mental disorders, including depression. It is thus possible to demonstrate the usefulness of caffeine and its derivatives in the treatment of depression. The main goal of... |
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The effects of lobeline on nicotine withdrawal-induced depression-like behavior in mice.
Psychopharmacol. Ser. 231(15) , 2989-98, (2014) Evidence suggests that neuronal nicotinic acetylcholine receptor (nAChR) ligand lobeline has antidepressant-like properties.The present study investigated the effects of lobeline on nicotine withdrawal-induced depression-like behavior.Adult C57BL/6J mice were... |