N-(3-Trifluoromethylphenyl)piperazine
N-(3-Trifluoromethylphenyl)piperazine structure
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Common Name | N-(3-Trifluoromethylphenyl)piperazine | ||
|---|---|---|---|---|
| CAS Number | 15532-75-9 | Molecular Weight | 230.230 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 305.9±42.0 °C at 760 mmHg | |
| Molecular Formula | C11H13F3N2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 138.8±27.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Detection of 1-benzylpiperazine and 1-(3-trifluoromethylphenyl)-piperazine in urine analysis specimens using GC-MS and LC-ESI-MS.
J. Anal. Toxicol. 32(6) , 444-50, (2008) Designer piperazines, such as 1-benzylpiperazine (BZP) and 1-(3-trifluoromethylphenyl)-piperazine (TFMPP), are widely available and have become popular party drugs throughout the world. Used in many countries as legal alternatives to methamphetamine and ecsta... |
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An analysis of legal highs: do they contain what it says on the tin?
Drug Test. Anal. 3(9) , 576-81, (2011) In recent years the availability of so-called legal highs over the Internet has hugely increased. Numerous online legal-high retailers market a broad variety of products which are advertised as research chemicals, bath salts, or plant food although clearly in... |
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Validation of an LC-MS method for the detection and quantification of BZP and TFMPP and their hydroxylated metabolites in human plasma and its application to the pharmacokinetic study of TFMPP in humans.
J. Forensic Sci. 55(5) , 1311-8, (2010) An LC-MS method was developed for benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP), constituents of "party pills" or "legal herbal highs," and their metabolites in human blood plasma. Compounds were resolved using a mixture of ammonium forma... |
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The stability of four designer drugs: MDPV, mephedrone, BZP and TFMPP in three biological matrices under various storage conditions.
J. Anal. Toxicol. 37(2) , 51-5, (2013) The analysis of designer drugs, including those in the synthetic cathinone and piperazine classes, may be complicated by the poor stability of these compounds in biological specimens. The stability of four of these compounds was investigated: 3,4-methylenedio... |
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Effects of trifluoromethylphenylpiperazine (TFMPP) on interhemispheric communication.
Psychopharmacology 213(4) , 707-14, (2011) 'Party Pills' containing trifluoromethylphenylpiperazine (TFMPP) and benzylpiperazine are legally available in many countries and marketed as safe alternatives to other illicit substances such as methamphetamine and methylenedioxymethamphetamine (or Ecstasy).... |
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Metabolic interactions with piperazine-based 'party pill' drugs.
J. Pharm. Pharmacol. 61(7) , 877-82, (2009) 'Party pills' have found use worldwide as a substitute for amphetamine-derived designer drugs. Whilst some information exists about the metabolism of these drugs, there is little information about their ability to inhibit the metabolism of co-administered dru... |
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Differences in harm from legal BZP/TFMPP party pills between North Island and South Island users in New Zealand: a case of effective industry self-regulation?
Int. J. Drug Policy 21(1) , 86-90, (2010) 'Party' pills containing benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) were sold legally in New Zealand until early 2008. Prospective studies of hospital emergency department admissions appeared to suggest that the harm from party pills w... |
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Current awareness of piperazines: pharmacology and toxicology.
Drug Test. Anal. 3(7-8) , 430-8, (2011) Although many piperazine derivatives exist, only a limited number have been studied, whereby they have been found to be generally stimulant in nature resulting from dopaminergic, noradrenergic, and predominantly serotoninergic effects in the brain. Reported t... |
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Patterns of benzylpiperazine/trifluoromethylphenylpiperazine party pill use and adverse effects in a population sample in New Zealand.
Drug Alcohol Rev. 27(6) , 633-9, (2008) A large legal market for party pills containing benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) developed in New Zealand after 2004. The use of these party pills has been associated with adverse health effects. The purpose of this paper was... |
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Trazodone, meta-chlorophenylpiperazine (an hallucinogenic drug and trazodone metabolite), and the hallucinogen trifluoromethylphenylpiperazine cross-react with the EMIT®II ecstasy immunoassay in urine.
J. Anal. Toxicol. 34(9) , 587-9, (2010) A series of patients whose urine screened positive for 3,4-methylenedioxymethamphetamine (MDMA) using a commercial enzyme immunoassay test (Ecstasy EMIT II assay), failed to confirm by substance-specific liquid chromatography-tandem mass spectrometry tests fo... |