1,3-Dimethyluric acid
1,3-Dimethyluric acid structure
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Common Name | 1,3-Dimethyluric acid | ||
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| CAS Number | 944-73-0 | Molecular Weight | 196.16300 | |
| Density | 1.63g/cm3 | Boiling Point | 520.2ºC at 760mmHg | |
| Molecular Formula | C7H8N4O3 | Melting Point | ≥300ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 268.4ºC | |
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Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids.
Bioorg. Med. Chem. Lett. 20 , 141-4, (2010) CTP synthase (CTPS) catalyzes the conversion of UTP to CTP and is a recognized target for the development of anticancer, antiviral, and antiprotozoal agents. Xanthine and related compounds inhibit CTPS activity (IC(50)=0.16-0.58mM). The presence of an 8-oxo f... |
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Uric acid may inhibit glucose-induced insulin secretion via binding to an essential arginine residue in rat pancreatic beta-cells.
Bioorg. Med. Chem. Lett. 15 , 1181-4, (2005) Uric acid (1a) suppresses basal insulin release in isolated rat pancreatic islets and inhibition of glucose-stimulated insulin secretion (GSIS) occurs right at hyperuricaemic levels (0.4 mM). Conversely, 1 mM guanidinium urate (2a) was completely ineffective,... |
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Effects of CYP inducers and inhibitors on the pharmacokinetics of intravenous theophylline in rats: involvement of CYP1A1/2 in the formation of 1,3-DMU.
J. Pharm. Pharmacol. 60(1) , 45-53, (2008) The types of hepatic cytochrome P450 (CYP) isozymes responsible for the metabolism of theophylline and for the formation of 1,3-dimethyluric acid (1,3-DMU) in rats in-vivo does not seem to have been studied at the dose ranges of dose-independent metabolic dis... |
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High-throughput liquid chromatography-tandem mass spectrometry assay for plasma theophylline and its metabolites.
Clin. Chem. 50(11) , 2176-9, (2004)
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Pharmacokinetics of theophylline metabolites in 8 Chinese patients.
Zhongguo Yao Li Xue Bao 19(5) , 437-9, (1998) To study theophylline metabolites pharmacokinetics in patients after a therapeutic dose.Eight adult patients with mild bronchial asthma and normal liver function were infused aminophylline intravenously (6.6 mumol.kg-1). The plasma concentrations of theophyll... |
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Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5.
J. Bacteriol. 191(14) , 4624-32, (2009) Pseudomonas putida CBB5 was isolated from soil by enrichment on caffeine. This strain used not only caffeine, theobromine, paraxanthine, and 7-methylxanthine as sole carbon and nitrogen sources but also theophylline and 3-methylxanthine. Analyses of metabolit... |
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Lack of effect of aciclovir on metabolism of theophylline and expression of hepatic cytochrome P450 1A2 in rats.
Biol. Pharm. Bull. 30(3) , 562-8, (2007) There is an interesting clinical report indicating that aciclovir, which is mainly excreted into urine, decreases the systemic clearance of theophylline by inhibiting cytochrome P450 (CYP) 1A2-mediated metabolism. In this study, we investigated the effect of ... |
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Development and validation of a sensitive LC-MS/MS method for the simultaneous quantitation of theophylline and its metabolites in rat plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 889-890 , 44-9, (2012) A rapid, specific, and reliable LC-MS/MS-based bioanalytical method was developed and validated in rat plasma for the simultaneous quantitation of theophylline and its four metabolites: 1,3-dimethyluric acid (1,3-DMU), 3-methylxanthine (3-MX), 1-methylxanthin... |
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Pharmacokinetics of intravenous theophylline in mutant Nagase analbuminemic rats.
Life Sci. 72(11) , 1231-45, (2003) It was obtained from our laboratories that the expression of hepatic microsomal cytochrome P450 (CYP) 1A2 increased approximately 3.5 times in mutant Nagase analbuminemic rats (NARs, an animal model for human familial analbuminemia), and theophylline was repo... |
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Lack of effect of olanzapine on the pharmacokinetics of a single aminophylline dose in healthy men.
Pharmacotherapy 18(6) , 1237-48, (1998) To test whether olanzapine, an atypical antipsychotic, is an inhibitor of cytochrome P450 (CYP) 1A2 activity, we conducted a drug interaction study with theophylline, a known CYP1A2 substrate.Two-way, randomized, crossover study.Clinical research laboratory.N... |