Bacampicillin hydrochloride
Bacampicillin hydrochloride structure
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Common Name | Bacampicillin hydrochloride | ||
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| CAS Number | 37661-08-8 | Molecular Weight | 501.98100 | |
| Density | N/A | Boiling Point | 695.4ºC at 760 mmHg | |
| Molecular Formula | C21H28ClN3O7S | Melting Point | 171-176° (dec) | |
| MSDS | N/A | Flash Point | 374.3ºC | |
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Ampicillin and its congener prodrugs in the horse.
Br. Vet. J. 150(2) , 173-87, (1994) Ampicillin is an antibiotic commonly administered to horses by both the intramuscular (i.m.) and the intravenous (i.v.) route. Its physicochemical properties restrict its absorption after oral administration and explain its rapid elimination from the body. To... |
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Eudragit E microspheres containing bacampicillin: preparation by solvent removal methods.
J. Microencapsul. 8(3) , 401-6, (1991) Eudragit E microspheres containing bacampicillin hydrochloride were prepared by solvent evaporation and solvent extraction methods. Three different systems of solvents were used: methyl acetate, acetone and methanol/liquid paraffin. The success of the procedu... |
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Ampicillin concentrations in radicular cysts following a single oral administration of bacampicillin.
Gen. Pharmacol. 24(4) , 895-8, (1993) 1. Ampicillin concentrations in cyst wall (wall) and cyst fluid (fluid) of radicular cyst and serum following a single oral administration of bacampicillin (equivalent to 500 mg of ampicillin) were measured by a paper disk method. 2. The mean peak concentrati... |
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Pharmacokinetics of bacampicillin in equids.
Am. J. Vet. Res. 56(11) , 1486-92, (1995) Bacampicillin hydrochloride is an ester prodrug that is hydrolyzed to ampicillin after its absorption from the gastrointestinal tract. It was administered intragastrically at a dose rate of 13.5 mg/kg of body weight to ponies and horses, and was highly bioava... |
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Ampicillin concentrations in human radicular granuloma following a single oral dose of bacampicillin.
J. Oral Maxillofac. Surg. 50(1) , 11-3, (1992) Ampicillin concentrations in human serum and radicular granulomas of 42 patients were determined after a single oral dose of bacampicillin (equivalent to 500 mg of ampicillin). Although wide variations were found among both serum and radicular granuloma ampic... |
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Bacampicillin hydrochloride: chemistry, pharmacology, and clinical use.
Pharmacotherapy 2(6) , 313-21, (1982) Bacampicillin hydrochloride is an orally administered ester of ampicillin that is rapidly and completely hydrolyzed in vivo to ampicillin. The most notable advantage of bacampicillin over ampicillin is its superior bioavailability--bacampicillin achieves sign... |
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Kinetic behavior and interaction of bacampicillin in alginic acid solution at neural pH region.
Chem. Pharm. Bull. 37(9) , 2485-90, (1989) Stabilization of bacampicillin (BAPC) in suspension was examined by the addition of alginic acid (Alg). BAPC formed a slightly water-soluble adduct (BAPC-Alg) with Alg, in which BAPC and Alg were presumed to be linked by ionic bonding. However, the suspension... |
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[Oesophageal ulcer associated with the use of bacampicillin].
Presse Med. 34(4) , 299-300, (2005) Many drugs may provoke oesophageal disorders. In France, doxycyclin, potassium chloride non-steroidal anti-inflammatories are the most frequent agents incriminated.A 27 year-old man consulted for dysphagia and odynophagia due to oesophagitis following adminis... |
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Bacampicillin uptake is shared with thiamine in Caco-2 cells.
Biol. Pharm. Bull. 30(7) , 1344-9, (2007) Bacampicillin was developed as a prodrug to improve the intestinal absorption of its metabolite ampicillin. This study was undertaken to characterize bacampicillin transport in Caco-2 cells. The uptake of bacampicillin in Caco-2 cells was significantly greate... |
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Study of bacampicillin hydrochloride durability in tablets.
Pharmazie 53(9) , 645-6, (1998)
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