Netilmicin sulfate
Netilmicin sulfate structure
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Common Name | Netilmicin sulfate | ||
|---|---|---|---|---|
| CAS Number | 56391-57-2 | Molecular Weight | 720.78 | |
| Density | 1.32 g/cm3 | Boiling Point | 684.3ºC at 760 mmHg | |
| Molecular Formula | C21H41N5O7.5/2H2O4S | Melting Point | >194ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 367.7ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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Polyhydroxyethylaspartamide-based micelles for ocular drug delivery.
Int. J. Pharm. 378(1-2) , 177-86, (2009) In this paper three copolymers of polyhydroxyethylaspartamide (PHEA), bearing in the side chains polyethylene glycol (PEG) and/or hexadecylamine (C(16)) (PHEA-PEG, PHEA-PEG-C(16) and PHEA-C(16) respectively) have been studied as potential colloidal drug carri... |
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Ocular penetration of topical antibiotics: study on the penetration of chloramphenicol, tobramycin and netilmicin into the anterior chamber after topical administration.
Clin. Experiment. Ophthalmol. 41(7) , 644-7, (2013) To compare penetration in the aqueous humour of topically applied antibiotics.Randomized prospective study, Department of Ophthalmology, University of Perugia, ItalyPatients undergoing cataract surgery.One hundred twenty-two patients were included: 14 receive... |
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Netilmicin-induced modulation of melanogenesis in HEMa-LP melanocytes.
Acta Pol. Pharm. 70(5) , 803-8, (2013) It is known that aminoglycoside antibiotics bind well to melanin biopolymer, but the relation between their affinity to melanin and ototoxicity is not well established. The aim of this work was to examine the impact of netilmicin on melanogenesis in cultured ... |
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Streptomycin interference in Jaffe reaction - possible false positive creatinine estimation in excessive dose exposure.
Clin. Biochem. 46(1-2) , 177-9, (2013) To study the potential of commonly used aminoglycoside antibiotics to form non-creatinine chromogen with alkaline picrate reagent.We studied the non-creatinine chromogen formation of various concentrations of streptomycin, amikacin, kanamycin, netilmicin, gen... |
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Development and validation of an improved reversed-phase liquid chromatographic method combined with pulsed electrochemical detection for the analysis of netilmicin.
J. Sep. Sci. 33(13) , 1897-903, (2010) Netilmicin is one of the aminoglycoside antibiotics that lacks a strong UV absorbing chromophore. However, the application of pulsed electrochemical detection has been used successfully for the direct analysis of aminoglycoside antibiotics. This study describ... |
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Cosubstrate tolerance of the aminoglycoside resistance enzyme Eis from Mycobacterium tuberculosis.
Antimicrob. Agents Chemother. 56(11) , 5831-8, (2012) We previously demonstrated that aminoglycoside acetyltransferases (AACs) display expanded cosubstrate promiscuity. The enhanced intracellular survival (Eis) protein of Mycobacterium tuberculosis is responsible for the resistance of this pathogen to kanamycin ... |
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Netilmicin in the neonate: pharmacokinetic analysis and influence of parenteral nutrition.
Pharm. World Sci. 31(3) , 365-8, (2009) The aim of this study was to investigate the impact of parenteral nutrition on netilmicin pharmacokinetics in critically ill neonates during the first week of life.A total of 200 neonates (gestational ages 26.4-41 weeks) treated with netilmicin (4-5 mg/kg in ... |
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Netilmicin sulfate: a comparative evaluation of antimicrobial activity, pharmacokinetics, adverse reactions and clinical efficacy.
Pharmacotherapy 3(6) , 305-15, (1983) Netilmicin, the 1-N-ethyl derivative of sisomicin, is a new aminoglycoside antibiotic that was recently marketed in the United States. Its role in therapeutics is not yet established. The pharmacokinetic profile of netilmicin is very similar to that of gentam... |
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The optimal aminoglycoside and its dosage for the treatment of severe Enterococcus faecalis infection. An experimental study in the rabbit endocarditis model.
Eur. J. Clin. Microbiol. Infect. Dis. 31(10) , 2545-7, (2012) Aminoglycosides are recommended for the treatment of Enterococcus faecalis infections, especially in severe and bacteremic infection. However, the optimal aminoglycoside or the optimal dosage remains uncertain. This study aimed to compare the activity of four... |
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In vivo antibacterial activity of vertilmicin, a new aminoglycoside antibiotic.
Antimicrob. Agents Chemother. 53(10) , 4525-8, (2009) Vertilmicin is a novel aminoglycoside antibiotic with potent activity against gram-negative and -positive bacteria in vitro. In this study, we further evaluated the efficacy of vertilmicin in vivo in systemic and local infection animal models. We demonstrated... |