Gemfibrozil
Gemfibrozil structure
|
Common Name | Gemfibrozil | ||
|---|---|---|---|---|
| CAS Number | 25812-30-0 | Molecular Weight | 250.333 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 394.7±30.0 °C at 760 mmHg | |
| Molecular Formula | C15H22O3 | Melting Point | 61-63°C | |
| MSDS | Chinese USA | Flash Point | 141.6±18.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
An orphan esterase ABHD10 modulates probenecid acyl glucuronidation in human liver.
Drug Metab. Dispos. 42(12) , 2109-16, (2014) Probenecid, a widely used uricosuric agent, is mainly metabolized to probenecid acyl glucuronide (PRAG), which is considered a causal substance of severe allergic or anaphylactoid reactions. PRAG can be hydrolyzed (deglucuronidated) to probenecid. The purpose... |
|
|
Analytical and biological characterization of halogenated gemfibrozil produced through chlorination of wastewater.
Environ. Sci. Technol. 46(10) , 5583-9, (2012) The cholesterol-lowering pharmaceutical gemfibrozil is a relevant environmental contaminant because of its frequency of detection in U.S. wastewaters at concentrations which have been shown to disrupt endocrine function in aquatic species. The treatment of ge... |
|
|
Monitoring and removal of residual phthalate esters and pharmaceuticals in the drinking water of Kaohsiung City, Taiwan.
J. Hazard. Mater. 277 , 53-61, (2014) This study monitored the occurrence and removal efficiencies of 8 phthalate esters (PAEs) and 13 pharmaceuticals present in the drinking water of Kaohsiung City, Taiwan. The simultaneous electrocoagulation and electrofiltration (EC/EF) process was used to rem... |
|
|
Azole antifungal inhibition of buprenorphine, methadone and oxycodone in vitro metabolism.
J. Anal. Toxicol. 39 , 374-86, (2015) Opioid-related mortality rates have escalated. Drug interactions may increase blood concentrations of the opioid. We therefore used human liver microsomes (HLMs) and cDNA-expressed human cytochrome P450s (rCYPs) to study in vitro inhibition of buprenorphine m... |
|
|
Hepatic uptake of atorvastatin: influence of variability in transporter expression on uptake clearance and drug-drug interactions.
Drug Metab. Dispos. 42(7) , 1210-8, (2014) Differences in the expression and function of the organic anion transporting polypeptide (OATP) transporters contribute to interindividual variability in atorvastatin clearance. However, the importance of the bile acid transporter sodium taurocholate cotransp... |
|
|
Rapid analysis of pharmaceuticals and personal care products in fish plasma micro-aliquots using liquid chromatography tandem mass spectrometry.
J. Chromatogr. A. 1383 , 104-11, (2015) A sensitive analytical method based on liquid-liquid extraction (LLE) and liquid chromatography tandem mass spectrometry (LC-MS/MS) was developed for rapid analysis of 11 pharmaceuticals and personal care products (PPCPs) in fish plasma micro-aliquots (∼20μL)... |
|
|
Ionization suppression effects with condensed phase membrane introduction mass spectrometry: methods to increase the linear dynamic range and sensitivity.
J. Mass Spectrom. 50(3) , 437-43, (2015) Condensed phase membrane introduction mass spectrometry (CP-MIMS) is an online analytical method that allows for the direct, trace level measurement of a wide range of analytes in complex samples. The technique employs a semi-permeable membrane that transfers... |
|
|
Ultra-high-performance liquid chromatography-Time-of-flight high resolution mass spectrometry to quantify acidic drugs in wastewater.
J. Chromatogr. A. 1423 , 96-103, (2015) A novel analytical approach involving an improved rotating-disk sorptive extraction (RDSE) procedure and ultra-high-performance liquid chromatography (UHPLC) coupled to an ultraspray electrospray ionization source (UESI) and time-of-flight mass spectrometry (... |
|
|
Eicosapentaenoic acid inhibits glucose-induced membrane cholesterol crystalline domain formation through a potent antioxidant mechanism.
Biochim. Biophys. Acta 1848(2) , 502-9, (2014) Lipid oxidation leads to endothelial dysfunction, inflammation, and foam cell formation during atherogenesis. Glucose also contributes to lipid oxidation and promotes pathologic changes in membrane structural organization, including the development of cholest... |
|
|
Bio-generation of stable isotope-labeled internal standards for absolute and relative quantitation of phase II drug metabolites in plasma samples using LC-MS/MS.
Anal. Bioanal. Chem 407 , 4053-63, (2015) Quantification of drug metabolites in biological samples has been of great interest in current pharmaceutical research, since metabolite concentrations and pharmacokinetics can contribute to a better understanding of the toxicity of drug candidates. Two major... |