Hydralazine hydrochloride
Hydralazine hydrochloride structure
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Common Name | Hydralazine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 304-20-1 | Molecular Weight | 196.637 | |
| Density | N/A | Boiling Point | 491.9ºC at 760 mmHg | |
| Molecular Formula | C8H9ClN4 | Melting Point | 273°C | |
| MSDS | Chinese USA | Flash Point | 251.3ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Aldehyde oxidase activity in fresh human skin.
Drug Metab. Dispos. 42(12) , 2049-57, (2014) Human aldehyde oxidase (AO) is a molybdoflavoenzyme that commonly oxidizes azaheterocycles in therapeutic drugs. Although high metabolic clearance by AO resulted in several drug failures, existing in vitro-in vivo correlations are often poor and the extrahepa... |
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Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms.
J. Pathol. 229(5) , 672-84, (2013) Mesangioproliferative glomerulonephritis is the most common nephritis worldwide. We examined the effects of low- and high-dose telmisartan, an angiotensin II receptor blocker, in rats with progressive anti-Thy1.1 mesangioproliferative glomerulonephritis in a ... |
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Critical blood pressure threshold dependence of hypertensive injury and repair in a malignant nephrosclerosis model.
Hypertension 64(4) , 801-7, (2014) Most patients with essential hypertension do not exhibit substantial renal damage. Renal autoregulation by preventing glomerular transmission of systemic pressures has been postulated to mediate this resistance. Conversely, malignant nephrosclerosis (MN) has ... |
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Coated hydralazine hydrochloride beads for sustained release after oral administration.
Drug Dev. Ind. Pharm. 39(9) , 1439-46, (2013) Hydralazine hydrochloride is an antihypertensive used alone or in combination with isosorbide nitrate for the treatment of congestive heart failure. Since control of blood pressure should be continuous, sustained release delivery of this drug is considered th... |
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Catecholaminergic C3 neurons are sympathoexcitatory and involved in glucose homeostasis.
J. Neurosci. 34(45) , 15110-22, (2014) Brainstem catecholaminergic neurons play key roles in the autonomic, neuroendocrine, and behavioral responses to glucoprivation, yet the functions of the individual groups are not fully understood. Adrenergic C3 neurons project widely throughout the brain, in... |
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Temporal endogenous gene expression profiles in response to lipid-mediated transfection.
J. Gene Med. 17(1-2) , 14-32, (2015) Design of efficient nonviral gene delivery systems is limited as a result of the rudimentary understanding of the specific molecules and processes that facilitate DNA transfer.Lipoplexes formed with Lipofectamine 2000 (LF2000) and plasmid-encoding green fluor... |
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Pharmacologic activation of tumor hypoxia: a means to increase tumor 2-deoxy-2-[18F]fluoro-D-glucose uptake?
Mol. Imaging 12(1) , 49-58, (2013) Tumor hypoxia and tumor metabolism are linked through the activation of metabolic genes following hypoxia-inducible factor 1 (HIF-1) activation. This raises the question of whether this relationship can be exploited to improve 2-deoxy-2-[(18)F]fluoro-D-glucos... |
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PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2.
Pharmacogenet. Genomics 24(8) , 409-25, (2014)
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Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling.
Nat. Commun. 6 , 6241, (2015) Hypertension induces structural remodelling of arteries, which leads to arteriosclerosis and end-organ damage. Hyperplasia of vascular smooth muscle cells (VSMCs) and infiltration of immune cells are the hallmark of hypertensive arterial remodelling. However,... |
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Inhibition of semicarbazide-sensitive amine oxidase attenuates myocardial ischemia-reperfusion injury in an in vivo rat model.
Leuk. Res. 88 , 302-6, (2011) This study tested the hypothesis that the inhibition of semicarbazide-sensitive amine oxidase (SSAO) after ischemia could attenuate myocardial ischemia-reperfusion (I/R) injury.Anesthetized male Sprague-Dawley rats underwent myocardial I/R injury. Saline, sem... |