Allopurinol
Allopurinol structure
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Common Name | Allopurinol | ||
|---|---|---|---|---|
| CAS Number | 315-30-0 | Molecular Weight | 136.111 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 290.8ºC at 760 mmHg | |
| Molecular Formula | C5H4N4O | Melting Point | 350 ºC | |
| MSDS | Chinese USA | Flash Point | 129.7ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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The efficacy of short and repeated high-pressure processing treatments on the reduction of non-O157:H7 Shiga-toxin producing Escherichia coli in ground beef patties.
Meat Science 102 , 22-6, (2015) High pressure processing (HPP) has previously been shown to be effective at reducing Escherichia coli O157:H7 in meat products. However, few studies have determined whether HPP may be effective at reducing non-O157:H7 Shiga toxin-producing E. coli (STEC) in g... |
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In vitro Xanthine Oxidase Inhibitory Studies of Lippia nodiflora and Isolated Flavonoids and Phenylethanoid Glycosides as Potential Uric Acid-lowering Agents.
Nat. Prod. Commun. 10 , 945-8, (2015) Lippia nodiflora has been traditionally used for treatment of knee joint pain. Hitherto, no studies have been reported on the effective use of L. nodiflora against hyperuricemia, gout or other metabolic disorders. In this present study, L. nodiflora was exami... |
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Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377.
Free Radic. Biol. Med. 83 , 214-26, (2015) High dietary fructose is an important causative factor in the development of metabolic syndrome-associated glomerular podocyte oxidative stress and injury. Here, we identified microRNA-377 (miR-377) as a biomarker of oxidative stress in renal cortex of fructo... |
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Evaluation of an electrochemical biosensor for uric acid measurement in human whole blood samples.
Clin. Chim. Acta 436 , 72-7, (2014) Uric acid measurement has become increasingly important, and electrochemically modified detection method based portable devices hold a dominant position in the market for point of care and self-monitoring of uric acid blood levels. However, there has been a l... |
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Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation.
Nat. Commun. 6 , 6555, (2015) Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present evidence that macrophage secretion of IL1β upon stimulation with ATP, crystals or LPS is mediated by a ra... |
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High-performance liquid chromatography coupled with post-column dual-bioactivity assay for simultaneous screening of xanthine oxidase inhibitors and free radical scavengers from complex mixture.
J. Chromatogr. A. 1345 , 50-6, (2014) Xanthine oxidase (XO) can catalyze hypoxanthine and xanthine to generate uric acid and reactive oxygen species (ROS), including superoxide anion radical (O₂(•-)) and hydrogen peroxide. XO inhibitors and free radical scavengers are beneficial to the treatment ... |
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Diagnostic and predictive performance and standardized threshold of traditional biomarkers for drug-induced liver injury in rats.
J. Appl. Toxicol. 35(2) , 165-72, (2014) Traditional biomarkers such as alanine and aspartate aminotransferase (ALT, AST) and total bilirubin (TBIL) have been widely used for detecting drug-induced liver injury (DILI). Although the Food and Drug Administration (FDA) proposed standardized thresholds ... |
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Effects of antioxidant agents against cyclosporine-induced hepatotoxicity.
J. Surg. Res. 193(2) , 658-66, (2015) To investigate the potential protective antioxidant role of ursodeoxycholic acid (UDCA), melatonin, and allopurinol treatment in cyclosporine (CsA)-induced hepatotoxicity.Hepatotoxicity was established in Sprague-Dawley rats by daily administration of CsA. Tr... |
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Assessment of the role of multidrug resistance-associated proteins in MPTP neurotoxicity in mice.
Ideggyogy. Sz. 66(11-12) , 407-14, (2014) The available scientific data indicate that the pathomechanism of Parkinson's disease (PD) involves the accumulation of endogenous and exogenous toxic substances. The disruption of the proper functioning of certain transporters in the blood-brain barrier and ... |
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Endothelial dysfunction impairs vascular neurotransmission in tail arteries.
Neurochem. Int. 80 , 7-13, (2015) The present study intends to clarify if endothelium dysfunction impairs vascular sympathetic neurotransmission. Electrically-evoked tritium overflow (100 pulses/5 Hz) was evaluated in arteries (intact and denuded) or exhibiting some degree of endothelium dysf... |