Iminostilbene
Iminostilbene structure
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Common Name | Iminostilbene | ||
|---|---|---|---|---|
| CAS Number | 256-96-2 | Molecular Weight | 193.244 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 349.1±22.0 °C at 760 mmHg | |
| Molecular Formula | C14H11N | Melting Point | 197 °C | |
| MSDS | Chinese USA | Flash Point | 178.4±17.8 °C | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Free-radical-scavenging effect of carbazole derivatives on AAPH-induced hemolysis of human erythrocytes.
Bioorg. Med. Chem. 15 , 1903-13, (2007) Since the research on antioxidants provides theoretical information for the medicinal development, and supplies some in vitro methods for quick-optimizing drugs, it attracts more scientific attention from bioorganic and medicinal chemists. In addition to the ... |
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Simulation of the hepatic metabolism of stilbene and its tricyclic derivatives by Fenton and Ruff reagents: models for cytochrome P-450 activation of chemical carcinogens.
Biopharm. Drug Dispos. 11(1) , 39-51, (1990) Reactions of trans-stilbene, cis-stilbene, 5H-dibenzo [a,d] cyclo-heptene 5-one and 5H-dibenz [b,f] azepine (iminostilbene) with Fenton reagent [Fe (II)/H2O2] clearly simulate their hepatic metabolism. Expoxidation on the corresponding ethylenic linkage was f... |
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Synthesis and antioxidant properties of some novel 5H-dibenz[b,f]azepine derivatives in different in vitro model systems.
Eur. J. Med. Chem. 45 , 2-10, (2010) A series of 5H-dibenz[b,f]azepine containing different aminophenols and substituted aminophenols were synthesized. 3-chloro-1-(5H-dibenz[b,f]azepine-5yl)propan-1-one (2) was obtained by N-acylation of 5H-dibenz[b,f]azepine (1) with 3-chloro propionyl chloride... |
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Determination of carbamazepine and its impurities iminostilbene and iminodibenzyl in solid dosage form by column high-performance liquid chromatography.
J. AOAC Int. 93(4) , 1059-68, (2010) An accurate and precise RP-HPLC method was developed and validated for the determination of carbamazepine and its impurities iminostilbene and iminodibenzyl in a tablet formulation with fluphenazine as an internal standard. Buffer-methanol (50 + 50, v/v) was ... |
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Carbamazepine metabolism to a reactive intermediate by the myeloperoxidase system of activated neutrophils.
Biochem. Pharmacol. 45(6) , 1267-75, (1993) Carbamazepine is an anticonvulsant which is associated with a significant incidence of hypersensitivity reactions including agranulocytosis. We have postulated that many drug hypersensitivity reactions, especially agranulocytosis and lupus, are due to reactiv... |
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Activation of T cells by carbamazepine and carbamazepine metabolites.
J. Allergy Clin. Immunol. 118(1) , 233-41, (2006) T-cell-mediated hypersensitivity is a rare but serious manifestation of drug therapy.To explore the mechanisms of drug presentation to T cells and the possibility that generation of metabolite-specific T cells may provoke cross-sensitization between drugs.A l... |
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Covalent binding of carbamazepine oxidative metabolites to neutrophils.
Drug Metab. Dispos. 23(5) , 590-4, (1995) Carbamazepine therapy is associated with several types of idiosyncratic drug reactions, including hematological disorders. In previous studies, we found that carbamazepine was metabolized by the myeloperoxidase/H2O2 system of activated neutrophils, and covale... |
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Effects of carbamazepine and metabolites on IL-2, IL-5, IL-6, IL-10 and IFN-γ secretion in epileptic patients: the influence of co-medication.
Pharmacol. Rep. 63(1) , 86-94, (2011) Carbamazepine is a widely used anticonvulsive agent. Its metabolic pathway leads not only to the major active metabolite, carbamazepine-10,11-epoxide, but also to minor terminal metabolites such as iminostilbene and acridine. Carbamazepine is usually well-tol... |
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Homogeneous substrate-labeled fluorescent immunoassay for carbamazepine.
Epilepsia 23(4) , 391-8, (1982) Carbamazepine is an anticonvulsant drug useful in the management of epilepsy. Because of the narrow therapeutic range, serum carbamazepine monitoring is useful for ensuring adequate drug therapy without toxicity. We report the development of a homogeneous sub... |
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Protective activity of aromatic amines and imines against oxidative nerve cell death.
Biol. Chem. 382(11) , 1601-12, (2001) Oxidative stress is a widespread phenomenon in the pathology of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Neuronal cell death due to oxidative stress may causally contribute to the pathogen... |