dimercaprol
dimercaprol structure
|
Common Name | dimercaprol | ||
|---|---|---|---|---|
| CAS Number | 59-52-9 | Molecular Weight | 124.225 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 223.4±0.0 °C at 760 mmHg | |
| Molecular Formula | C3H8OS2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 89.1±18.2 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury.
Am. J. Physiol. Lung Cell. Mol. Physiol. 307(12) , L987-97, (2014) Microvascular barrier integrity is dependent on bioavailable nitric oxide (NO) produced locally by endothelial NO synthase (eNOS). Under conditions of limited substrate or cofactor availability or by enzymatic modification, eNOS may become uncoupled, producin... |
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Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration.
PLoS ONE 10(4) , e0123460, (2015) Ventilator-induced lung injury is a form of acute lung injury that develops in critically ill patients on mechanical ventilation and has a high degree of mortality. Nicotinamide phosphoribosyltransferase is an enzyme that is highly upregulated in ventilator-i... |
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Safety and biocompatibility of carbohydrate-functionalized polyanhydride nanoparticles.
AAPS J. 17(1) , 256-67, (2015) Carbohydrate functionalization of nanoparticles allows for targeting of C-type lectin receptors. This family of pattern recognition receptors expressed on innate immune cells, such as macrophages and dendritic cells, can be used to modulate immune responses. ... |
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Hemagglutinin-based polyanhydride nanovaccines against H5N1 influenza elicit protective virus neutralizing titers and cell-mediated immunity.
Int. J. Nanomedicine 10 , 229-43, (2015) H5N1 avian influenza is a significant global concern with the potential to become the next pandemic threat. Recombinant subunit vaccines are an attractive alternative for pandemic vaccines compared to traditional vaccine technologies. In particular, polyanhyd... |
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Protease inhibitor reduces airway response and underlying inflammation in cockroach allergen-induced murine model.
Inflammation 38(2) , 672-82, (2015) Protease(s) enhances airway inflammation and allergic cascade. In the present study, effect of a serine protease inhibitor was evaluated in mouse model of airway disease. Mice were sensitized with cockroach extract (CE) or Per a 10 and treated with 4-(2-amino... |
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Leukocyte-specific protein 1 regulates neutrophil recruitment in acute lung inflammation.
Am. J. Physiol. Lung Cell. Mol. Physiol. 309 , L995-1008, (2015) The mechanisms of excessive migration of activated neutrophils into inflamed lungs, credited with tissue damage, are not fully understood. We explored the hitherto unknown expression of leukocyte-specific protein 1 (LSP1) in human and mouse lungs and neutroph... |
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T cells and lung injury. Impact of rapamycin.
Am. J. Respir. Cell. Mol. Biol. 51(2) , 294-9, (2014) Acute lung injury (ALI) is characterized by pulmonary inflammation and edema. Innate immune cells (e.g., neutrophils and macrophages) are major contributors to inflammation in ALI. Less is known regarding the role of T cells. We examined the effects of rapamy... |
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TRAF4-SMURF2-mediated DAZAP2 degradation is critical for IL-25 signaling and allergic airway inflammation.
J. Immunol. 194(6) , 2826-37, (2015) IL-25 promotes type 2 immunity by inducing the expression of Th2-associated cytokines. Although it is known that the IL-25R (IL-17RB) recruits the adaptor protein ACT1, the IL-25R signaling mechanism remains poorly understood. While screening for IL-25R compo... |
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The Aspergillus fumigatus sitA Phosphatase Homologue Is Important for Adhesion, Cell Wall Integrity, Biofilm Formation, and Virulence.
Eukaryotic Cell 14 , 728-44, (2015) Aspergillus fumigatus is an opportunistic pathogenic fungus able to infect immunocompromised patients, eventually causing disseminated infections that are difficult to control and lead to high mortality rates. It is important to understand how the signaling p... |
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HSP90 inhibition suppresses lipopolysaccharide-induced lung inflammation in vivo.
PLoS ONE 10(1) , e0114975, (2015) Inflammation is an important component of cancer diathesis and treatment-refractory inflammation is a feature of many chronic degenerative lung diseases. HSP90 is a 90kDa protein which functions as an ATP-dependent molecular chaperone that regulates the signa... |