KT-109
KT-109 structure
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Common Name | KT-109 | ||
|---|---|---|---|---|
| CAS Number | 1402612-55-8 | Molecular Weight | 422.522 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 637.3±53.0 °C at 760 mmHg | |
| Molecular Formula | C27H26N4O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 339.3±30.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.
Nat. Chem. Biol. 8(12) , 999-1007, (2012) The endocannabinoid 2-arachidonoylglycerol (2-AG) is biosynthesized by diacylglycerol lipases DAGLα and DAGLβ. Chemical probes to perturb DAGLs are needed to characterize endocannabinoid function in biological processes. Here we report a series of 1,2,3-triaz... |
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Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis.
J. Med. Chem. 56(21) , 8257-69, (2013) We have previously shown that 1,2,3-triazole ureas (1,2,3-TUs) act as versatile class of irreversible serine hydrolase inhibitors that can be tuned to create selective probes for diverse members of this large enzyme class, including diacylglycerol lipase-β (D... |
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Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation.
J. Biol. Chem. 289(3) , 1491-504, (2014) Perturbation of calcium signaling that occurs during cell injury and disease, promotes cell death. In mouse lung fibroblasts A23187 triggered mitochondrial permeability transition pore (MPTP) formation, lactate dehydrogenase (LDH) release, and necrotic cell d... |