3',4'-DICHLOROBENZAMIL HYDROCHLORIDE
3',4'-DICHLOROBENZAMIL HYDROCHLORIDE structure
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Common Name | 3',4'-DICHLOROBENZAMIL HYDROCHLORIDE | ||
|---|---|---|---|---|
| CAS Number | 928621-15-2 | Molecular Weight | 425.1 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H13Cl4N7O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Amiloride derivatives are potent blockers of KATP channels.
Naunyn Schmiedebergs Arch. Pharmacol. 364(4) , 351-8, (2001) In cardiomyocytes sarcolemmal KATP channels open massively when the cytosolic [ATP] drops into the range of tens of micromolar, as during acute ischemia. The diuretic drug amiloride and related derivatives are well established as drugs blocking the Na+/H+- an... |
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Modulation of neuroprotective effect of ischemic post-conditioning by dichlorobenzamil a Na(+)/Ca(2+) exchanger inhibitor in mice.
Biol. Pharm. Bull. 33(4) , 585-91, (2010) The present study has been designed to investigate the modulatory role of dichlorobenzamil a Na(+)/Ca(2+) exchanger inhibitor in ischemic post-conditioning-induced neuroprotection in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a... |
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Stimulation of large-conductance Ca2+-activated K+ channels by the Na+/Ca2+ exchanger inhibitor dichlorobenzamil in cultured human umbilical vein endothelial cells and mouse aortic smooth muscle cells.
J. Physiol. Pharmacol. 60(1) , 43-50, (2009) We investigated the effects of the selective inhibitor of Na(+)/Ca(2+) exchanger (NCX), 2',4'- and 3',4'-dichlorobenzamil (DCB), on large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels in cultured human umbilical vein endothelial cells (HUVECs) and fresh... |
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Spontaneous gating of olfactory cyclic-nucleotide-gated channels.
J. Membr. Biol. 178(1) , 49-54, (2000) In vertebrates, cilia on the olfactory receptor neurons have a high density of cyclic-nucleotide-gated (CNG) channels. During transduction of odorous stimuli, cyclic AMP is formed. cAMP gates the CNG channels and this initiates the neuronal depolarization. He... |
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Modulation of the Ca(2+) release channel of sarcoplasmic reticulum by amiloride analogs.
Eur. J. Pharmacol. 391(1-2) , 11-20, (2000) Dichlorobenzamil, phenamil and other amiloride analogs (1-100 microM) elicit transient tension in rabbit skinned muscle fibers. Tension requires preloading of Ca(2+) into the sarcoplasmic reticulum, is facilitated by low-[Mg(2+)] solutions, abolished by ruthe... |
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Intrasperm Ca2+ modulation and human ejaculated sperm viability: influence of miconazole, clotrimazole and loperamide.
J. Pharm. Pharmacol. 58(8) , 1145-51, (2006) Elevation of intrasperm Ca(2+) is reported to influence viability of ejaculated spermatozoa. Human spermatozoa possess inositol triphosphate (IP(3))-sensitive Ca(2+) stores, which can be targeted for increasing intrasperm Ca(2+) level. The influence of agents... |
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External bioenergy-induced increases in intracellular free calcium concentrations are mediated by Na+/Ca2+ exchanger and L-type calcium channel.
Mol. Cell Biochem. 271(1-2) , 51-9, (2005) External bioenergy (EBE, energy emitted from a human body) has been shown to increase intracellular calcium concentration ([Ca2+]i, an important factor in signal transduction) and regulate the cellular response to heat stress in cultured human lymphoid Jurkat... |
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N(omega)-nitro-L-arginine decreases resting cytosolic [Ca2+] and enhances heat stress-induced increase in cytosolic [Ca2+] in human colon carcinoma T84 cells.
Chin. J. Physiol. 42(3) , 153-9, (1999) N(omega)-nitro-L-arginine (LNNA) inhibits the synthesis of heat shock proteins in animals and cultured cells exposed to heat stress. Heat shock protein synthesis is known to be Ca2+-dependent. In this study, we have characterized the effect of LNNA on [Ca2+]i... |
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Physiological role of the sodium-calcium exchanger in tracheal smooth muscle of guinea pig.
J. Muscle Res. Cell Motil. 25(8) , 620-1, (2004)
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Studies on cerebral protection of digoxin against ischemia/reperfusion injury in mice.
Yakugaku Zasshi 129(4) , 435-43, (2009) The present study was designed to investigate the possible neuroprotective effect of digoxin induced pharmacological preconditioning (PP) and its probable mechanism. Bilateral carotid artery occlusion (BCAO) of 17 min followed by reperfusion for 24 h was empl... |